Charles W. Shuff moved to Greenville, N.C. in May 1922 as branch manager of the Imperial Tobacco Company. Shuff and his wife, Hattie Pitts Shuff, bought a lot on Fifth Street from J.M. and Walter L. Harrington on April 1, 1924. On this lot, they built the Shuff House, one of the largest Colonial Revival houses in Greenville, in 1925. They raised three children there, and their daughter Phyllis C. Shuff and her husband Joseph Smith, Jr. moved into the house. Christopher Woelkers purchased the Shuff house and turned it into \"The 5th Street Inn,\" Greenville's first bed & breakfast inn.