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America's leading killer-disease in the early 20th-century was tuberculosis. When 65 cases were reported in Guilford County in 1915 and 125 people died from it in 1920, a movement developed to build a sanatorium. The Guilford County Sanatorium opened in 1924, and averaging 120 patients at a time, the sanatorium provided quality care until it closed in 1955. In 1958, the Guilford Technical Community College opened and used the buildings for another ten years when they were replaced with newer ones.