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William "Bill" Cain papers contain materials from his career at ECU and personal items.

This Record Group contains records, including annual reports, from various areas of University Advancement.

This collection includes correspondence and memos from the Department of Materials Management, as well as the Purchasing Buyline newsletter.

Congressional files (1966-1992), of businessman and Democratic mayor of Farmville, NC, 1949-1953; state representative, 1955-1959; state senator, 1965; and U. S. Congressman from the 1st District of NC, 1966-1989, including correspondence, reports, legislative bills, memorandums, clippings, etc. 378 boxes. 126.0 cubic feet.

The collection includes various aspects of public health in North Carolina beginning in the early 20th century.

This collection contains official publications of the Division of Student Affairs including brochures and flyers, as well as annual reports, policy manuals and guidebooks. The collection also contains memos and rules and regulations from the Student Health Service and mission statements from the Department of Recreational Services and the Department of University Housing.

Communications from East Carolina University, Pitt County, and The United states regarding the COVID-19 Pandemic.

This collection contains a single photograph album that highlights the Sandhills region in North Carolina from 1914 to 1921.

This collection contains Forrest Foster's materials from his time as a student and football player at East Carolina.

This collection contains Grover Truslow's materials from his time as an alumnus and football player at East Carolina.

This collection contains reports about the department from the American Council for Construction Education, as well as brochures and a publication.

The Charles S. Sterrett Collection contains one print of the USS Wisconsin (BB-64) from 1945.

Autographed photographs of Naval officers and prints from the U.S. Naval Institute Proceedings Cover Piuctures Series

Collection holds medical notebooks from various sources. Two notebooks found in the Laupus Library History Collection with no presently known provenance. One notebook is a dietetics notebook from E. Alexander at General Hospital, Patterson, New Jersey. The other notebook is Dr. Edward Beach Crowell's medical recipe book. An additional notebook was added to the collection in 2018. This notebook, purchased from Palinurus, was the business record for a Connecticut physician in the 1840s. Two more notebooks were added in 2022. They document medical products.

Collection (1901-1926) of correspondence received by Maud Smith (née Tyson) and her husband Walter Edward "Edd" Smith, from family and friends. Collection includes letters to Maud Tyson, while she attended Littleton Female College, letters from Carl Tyson, during World War I, from the Headquarters of the 81st Division, at Camp Jackson, South Carolina, between May and November, 1918, and several other letters, as well as a list of transcripts and typed transcripts of all letters in the collection.