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The collection consists primarily of photographic, blueprint, journals, class photos, and other advertising materials used and/or created by the Medical News & Information department of East Carolina University.

This collection contains correspondence (August 1941-June 1942, undated) between Richard H. Owen and his parents, especially his mother Mrs. M. A. Owen in Miami, Florida, while he was serving aboard the USS Crescent City and stationed at the U.S. Naval Air Station at Corpus Christi, Texas. Also included is a notepad containing First Aid lessons and addresses.

Collection of church records, including a ledger (1926-1934, undated) and loose reports, notes, financial accounts, lists of church officers and members, minutes of church meetings and committees, and printed materials, etc.

Genealogical materials for Dixon, Haddock, Hemby, Laughinghouse, Nelson, Jenkins, Baldree, Dail-Deal, Flake, Kittrell and other families of Pitt County, NC. Also includes local history and biographical sketches by William B. Kittrell, a DVD of a Motion picture of Greenville, North Carolina (ca. 1940s-1950s) showing ordinary daily scenes and local buildings, CD of early 20th Century Pitt County schools, and 2 DVDRs made from 8mm reels of home movies (1947-1967) made by the Keel family of Greenville, N.C.

Records (1891-1908), including: Box 1 a) Cash Book, Aug. 1891-July 1894; b) Journal #2, Aug. 1894-Aug. 1902. 222 pages used out of 222; c) Cash Book, Aug. 1895-Dec. 1896; Box 2: a) Account Book, Sept. 1897-Aug. 1898. 66 pages used out of 184; b) Journal, Aug. 1899-Sept. 1903. 126 pages used out of 296; Box 3: a) Journal A., May 1902-Jan. 1908. 222 pages used out of 500.

Papers (1929-1961, 1982) including correspondence, photographs, citations, reports, war diaries for USS Zane and Trever, accounts of battles at Pearl Harbor and Guadalcanal, publications, orders, and personal materials.

Issue No. LXXIX (1/13/1790) of the Gazette of the United States newspaper containing the announcement of the Adoption and Ratification of the Constitution of the United States by the State of North Carolina, signed in type by President George Washington, p.313-316, (4 p.), published by John Fenno, New York, and autographed "[Moses] Ogden."

Papers (1920-1975) including correspondence, reports, financial records, clippings, photographs, posters, and miscellaneous materials.

Letters and ephemera (1926-1929) related to the life of Agnes Wadlington [Barrett], who was born in Trigg County, Kentucky in 1902, before she took a job at East Carolina Teachers College (now East Carolina University) as secretary to the president of the college. Also found with these papers are many photographs of members of the Putnam family of Murray, Kentucky. The only connection between Mrs. Barrett and the Putnam family appears to be that both she and Louise Vey Putnam Carter's husband Herbert Leland Carter both worked at East Carolina University. An 1982 engagement calendar kept by Mrs. Barrett documents her life during retirement in Greenville, North Carolina.

Collection (1945-circa 1980s, undated) of clippings, photographs, Christmas cards, World War II ration books, relating to the Parker family, "Pitch a Boogie Woogie" a film with an all-black cast, the Corner Stone Baptist Church, and Mt. Calvary Free Will Baptist Church of Greenville, North Carolina.

Papers (1930-1949) including correspondence; agriculture and gardening; export of flowers and vegetables; travel account; letters and miscellaneous.

Photographs and negatives of African American minstrel show performers (most, if not all, are members of Silas Green from New Orleans show) both on and off stage. These negatives and photographs were made from the originals (1932-1942, undated) in 1998 and the whereabouts of the originals are unknown. Charles Morton starred as Little Charlie Morton Jr. with the Silas Green from New Orleans tent travelling show and posters listed him as Silas Green's youngest star.

The Woman's Club of Greenville, NC, was founded in April 1917 intending to raise Greenville to be equal with other cities in the state. Catherine "Kitty" Smith Joyner (b. 4 June 1932 – d. 2 Aug 2011), a native of Greenville N.C., worked with the Woman's Club of Greenville, NC, in the 1990's. This collection includes photographs of Greenville, N.C., and other locations in Pitt County, as well as a publication detailing the first fifty years of the Woman's Club of Greenville, NC.

Collection (1848-1931) of Johnston County (NC) family including journal, will, deeds, letter, certificates, etc.

This collection includes a ledger book containing records (August 1882-December 1996) of the Red Banks Primitive Baptist Church located at the intersection of Fourteenth Street and Fire Tower Road in Greenville, North Carolina. The church was founded in 1758, but the present building was built in 1893. Included are minutes of the Conference meetings (1882-1996) which also mention when members join or leave or die, lists of some of the members with identifying information related to membership status, and loose papers. Also included are a treasurer's book (1964-2000) and a minutes book (1990-2000).