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Journal of a Cruize in the USS Independence, Commodore William Bainbridge's Flag Ship, Capt. William M. Crane, Commander, from Boston, July 2nd, 1815 (3 July–15 November 1815), compiled by an anonymous crew member, which describes the first overseas mission of the first ship of the line commissioned by the United States Navy, to deal with the piratical acts of the Barbary Powers against American merchant commerce in the Mediterranean Sea, bound in original calf leather over marbled boards, entries clean and legible; also a letter from William M. Crane, Commanding Officer, USS Delaware, Port Mahon (20 September 1829) to Lt. William N, McKean, U.S. sloop Warren, ordering him to report to Lt. Thomas M. Newell, commander of the U.S. schooner Porpoise.

Papers [1908-1911] including correspondence, photographs, miniature photographs, inspection, off-duty activities of marines and sailors, etc.

Papers (1858-1910) including correspondence, financial materials, common medical procedures, payments, tax listings, correspondence from insurance companies, patient entries, etc.

Collection (1763-2013) including correspondence, financial records, legal records, clippings, land records, photographs, clippings, poetry, genealogy and miscellaneous files compiled by William L. Murphy related to genealogy research in Eastern North Carolina.

Photograph album compiled by Ethel May Burt (ca. 1900) consisting primarily of photographic prints documenting Edenton, Chowan County, N.C., but also including views of various towns including Belhaven and Louisburg, N.C., and Claremont, Corbin Point, James River, and Portsmouth, Va., focusing on street scenes. Also includes also photos of families and friends; White and African American residents; the sitting rooms of Mrs. C. B. Elliott and Mrs. R. L. Temple; and images of notable sites, including Chowan County Courthouse, Dr. Richard Dillard and his front yard, Sailboat ELIZABETH, Norfolk & Southern Railway Stations and Depots, Edenton Bay, U.S. "Fish Pond" and Fish Hatchery, Bank of Edenton, Edenton Cotton Mill interior and exterior views, Methodist church, C. B. Elliott residence, Magnolia Street, "Dr. Capehart's Fishery", Steamer WAGNER of the Norfolk & Southern Railway Line, Ship BOUTWELL and Captain W. S. Howland, Cherry's Point, Holley's Wharf, Tar River, and "Lover's Leap."

Records (1981-1987), including correspondence, minutes, programs, clippings, literary manuscripts, photographs, and scrapbooks.

The Henry Ferrell Papers include professional and personal correspondence, committee and departmental reports, materials related to his scholarly works and research, including the book "No Time for Ivy," and materials related to his participation in professional and civic organizations.

Journal (1905-1906) consisting of reminiscences, historical, genealogical notations, insurance, autobiographical sketch, textbooks, journal entries of salaries, etc.

The collection includes correspondence, minutes, programs, lists, dues information, journal reprints and articles, newsletters, receipts, clippings, reports, and photographs. Addition of January 2017 includes programs, newsletters, photographs, books, articles, clippings, deceased members files, Country Doctor Museum and East Carolina University alliance, and transcription project of the Country Doctor Museum oral histories.

Files (1969-1994) belonging to retired ECU Biology professor Dr. Vincent J. Bellis pertaining to the environmental impact of the Chicod Creek (North Carolina) channelization, the East Carolina University Institute for Coastal and Marine Resources, North Carolina Academy of Science, and material concerning the Sierra Club of NC and other environmental groups. Included are correspondence, affidavits, reports, notes, conference proceedings, environmental studies, and newsletters.

Papers (1925-1974, undated) consisting of diaries, correspondence, photographs, certificates, citations, newspaper, clippings, magazine articles, etc. and miscellaneous.

Papers (1764-1910) including correspondence, land records, account sales, a photograph, agricultural reports, receipts and miscellaneous.

Personal files created by Pitt County, North Carolina, native Mary Perkins-Williams relate to the Pitt County Black Assembly (1979, 1983), NAACP Legal Defense (1980), regional development (1977-1979), minority issues, and fair housing. Audio-Visual Materials include photographs of scrapbook images (ca. 1950s) documenting both abandoned and active Pitt County, North Carolina, African American public schools. Also included are seven videocassettes documenting a grant-funded oral history project completed in 1994 entitled Growing up African-American in Pitt County.

Records (1937-1960) including correspondence, work orders, product invoices, requisitions, receipts, advertisements, photographs, and publications.

Registers (1784-1858) including newspaper clippings, geographical information, handwritten pages, details of war events and miscellany.