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This collection (1880s-1980s) concerns the Holt family of Smithfield in Johnston County, North Carolina, and the Henderson family in Conecuh County, Alabama, and the Wilson family of Harrison and Detroit, Michigan who are related through marriage. The Holt family material mainly concerns William and Nancy Holt and their children and includes correspondence, diaries, school records, 16 mm films, photographs, and documents such as oil and gas leases in Texas related to William's work with The Texas Company (part of Texaco). The larger portion of the material is related to the other two families and includes correspondence, photographs (tintypes through color snapshots), ledger books and deeds (many related to timber purchases in Alabama and Michigan), and undated plat books for Michigan.

The collection includes correspondence, minutes, programs, lists, dues information, journal reprints and articles, newsletters, receipts, clippings, reports, and photographs. Addition of January 2017 includes programs, newsletters, photographs, books, articles, clippings, deceased members files, Country Doctor Museum and East Carolina University alliance, and transcription project of the Country Doctor Museum oral histories.

Collection (1950 - 2011), including correspondence, photographic prints, ephemera, subject files and published materials, relating to Democratic Party politics in North Carolina and Washington, DC, especially Leggett's activities as chief of staff for Robert B. Morgan, who was Attorney General of North Carolina and U. S. Senator, 1970-1980.

This collection contains records of Eric G. Flannagan & Sons architectural firm that relate to capital projects on the East Carolina campus.

Papers (1943-1945) including correspondence with references made to signaling, semaphore operations, mail delivery problems, etc.

Collection (1803-1996) pertaining to Martin County, NC, farmer John Conrad Getsinger, Sr., (Nov. 4, 1812-Jan. 16, 1891), a native of Wurttemburg, Germany, and several of his descendants consisting of correspondence, memoranda books, a sketchbook created by Mr. Getsinger while he was a soldier (1847-1848) fighting in the Mexican War, financial records, Civil War records pertaining to Mr. Getsinger and his son John C. Getsinger, Jr., religious publications, Primitive Baptist Church records (especially for Smithwick's Creek Primitive Baptist Church), pamphlets, broadsides, photographs, legal papers, newspaper clippings, and miscellany.

Papers (1941-1970) of Naval officer, USNA class of 1941, consisting of scrapbooks, containing clippings, correspondence, reports, photographs, memorabilia, orders. Also includes biographical information and 2016 obituary.

Original material collected by Horace H. Mewborn, Jr. including printed maps, letters, diaries, clippings, cartes de visite, tintypes, an ambrotype, memoir, ledgers, reports, and drawings related to the Civil War especially pertaining to Col. John S. Mosby and his 43rd Virginia Cavalry Battalion, Col. Elijah V. White and his 35th Virginia Cavalry Battalion, North Carolina Cavalry Units, and the battles fought in the New Bern, NC, vicinity. Also included is his voluminous research related to the above listed units and the Army of Northern Virginia and the Army of the South.

This collection contains the congressional files for U.S. House of Representatives member Walter B. Jones, Jr., who represented the 3rd Congressional District of North Carolina from 1995 until his death in 2019. Included are files, scrapbooks, media, and electronic files. The electronic files were created by his staff and included speeches, correspondence, articles, promotional material, notes and videos for the years 2005-2018.

William and Harry Whittaker were brothers who both served in the U.S. Army during the Vietnam War. William mainly served in West Germany while Harry was sent to Vietnam in 1967. Their letters to each other cover the years 1964 to 1968 and discuss both basic training in Fort Dix, New Jersey, and Fort Jackson, South Carolina, and their service in West Germany and Vietnam. Also included are numerous photographs taken by Harry while he was stationed in Vietnam.

Collection contains the records of former Vice Chancellor for Institutional Advancement Robert Holt, including correspondence, reports, clippings, and publications.

The Records of East Carolina Men's Basketball are comprised of press handbooks, media guides, gameday programs, and game footage.

This collection contains a items related to student life and academics at East Carolina including certificates, event programs, brochures, and memorabilia.

Records (1981-1987), including correspondence, minutes, programs, clippings, literary manuscripts, photographs, and scrapbooks.

This collection contains the records (1873-2010) of the fraternal secret society Knights of Pythias Grand Lodge, Domain of North Carolina. Records include biennial and annual reports of local lodges, the Records of Proceedings for the annual sessions of the Grand Lodge, financial records, minute book, constitutions and bylaws, publications and items such as the 1909 Pythian Service Book.