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The collection includes publications created by the ECU School of Medicine and the University Health Systems of Eastern Carolina, formerly Pitt County Memorial Hospital.

Collection (1848-2002) of Pace family papers, including documents; photograph and postcard albums; scrapbooks; loose photographs, deeds, legal documents, and newspaper clippings; printed yearbooks, catalogs, textbooks, and newspapers; genealogical charts, postcards, brochures, World War I Army Medical Corps documents, and ephemera relating to physician Dr. Karl Busbee Pace, Sr. and his sons, Dr. Karl B. Pace, Jr., Charles Taylor Pace, and J. T. W."Tommy" Pace and their families in Robeson, Chatham and Pitt counties, NC.

Papers (1791, 1846-1941) including correspondence, diaries, visitation books, account books, memoranda books, financial papers, minute books, photographs, land records and miscellaneous.

The Watson and Boomer families of Beaufort and Hyde Counties, North Carolina, were connected through marriage. Included are original deeds from the early and mid-1800s; birth, death, and marriage dates and genealogy notes; baby book-type notes about the lives of 2 children (1885-1888) of William I. Watson (his mother was a Boomer) and wife "Ms. Charlie" Sidney Archbell Watson; World War I letters (1917-1918) written by William E. Watson to relatives in Aurora (Beaufort County), North Carolina, from Camp Sevier and Fort Jackson in South Carolina; and photographs (late 1800s-early 1900s).

Correspondence (9/23/1893 - 3/16/1915) between Julia Caroline Arthur Burgess, William Batters "Bat" Burgess, Martha Theresa Arthur "Mattie" Burgess, Nancy Eugenia Arthur, Sarah Lucretia "Creatia" Arthur, of Washington, New Bern, Greenville, Kinston, and Ernul NC (16 manuscript letters, 1 photocopy and 6 envelopes); Descendants of James Gilbert Gatlin, Jr.) genealogical inventory, 1766-1999, (5 p. typescript manuscript) and inventory of letters,

Papers of Donald Davidson (1981, 1986) documenting the life and literary career of the noted Giles County, Tennessee-born American poet, essayist, social and literary critic and author; consisting of a printed broadside of his poem An Epinician Ode in Honor of John Crowe Ransom, published by Palaemon Press (1981); noted by Stuart Wright on verso: typescript is signed by Donald Davidson 'At Bread Loaf, Vermont / July 28, 1958; also including a letter from M. Thomas Inge to Stuart Wright (1986) concerning the possible publication of Inge's correspondence with Davidson.

Papers (1943–1945) including copies of correspondence, personal notations, orders, addresses, photographs, reminiscences, equipment lists, and reports pertaining to his World War II service with the 14th Malaria Control Unit of the U.S. Army Air Corps in New Guinea and the Philippines, 1943–1945, including references to malaria control, military issues, and incidents involving Japanese, American and Filipino forces.

This collection contains a single Civil War Diary (October 1, 1862 - March 24, 1863) kept by William H. H. Leach.

Includes commencement programs, invitations, and other printed material related to spring, summer, and fall commencements.

The Louis Orr Collection contains a set of forty-eight prints of the original fifty-one print set (and one replacement print) made from etchings of North Carolina historical landmarks and architectural sites. The etchings were created from 1939 to 1952 by artist Louis Orr, a world-renown etcher, at the behest of North Carolina resident Robert Lee Humber who wanted to preserve North Carolina's heritage by providing the artwork to schools, colleges, public libraries and institutions throughout the state.

This collection contains records of Eric G. Flannagan & Sons architectural firm that relate to capital projects on the East Carolina campus.

The collection includes correspondence and some photographic material documenting the service of Richard Lewis Kinney (1927-2015) of Lexington, North Carolina in the United States Army in occupied Japan at the end of World War II. The collection provides a glimpse of an American soldier's point of view and experience serving overseas during the post-war occupation of Japan.

Papers [1908-1911] including correspondence, photographs, miniature photographs, inspection, off-duty activities of marines and sailors, etc.

Collection (ca. 1802-1951) of material compiled by members of Christ Episcopal Church of Elizabeth City, North Carolina, related to the church's history including photographs, blueprints, correspondence, scrapbooks, church history booklets, annual reports, parish yearbooks, programs, clippings, and budget documents.