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Collection holds medical notebooks from various sources. Two notebooks found in the Laupus Library History Collection with no presently known provenance. One notebook is a dietetics notebook from E. Alexander at General Hospital, Patterson, New Jersey. The other notebook is Dr. Edward Beach Crowell's medical recipe book. An additional notebook was added to the collection in 2018. This notebook, purchased from Palinurus, was the business record for a Connecticut physician in the 1840s. Two more notebooks were added in 2022. They document medical products.

The Louis Orr Collection contains a set of forty-eight prints of the original fifty-one print set (and one replacement print) made from etchings of North Carolina historical landmarks and architectural sites. The etchings were created from 1939 to 1952 by artist Louis Orr, a world-renown etcher, at the behest of North Carolina resident Robert Lee Humber who wanted to preserve North Carolina's heritage by providing the artwork to schools, colleges, public libraries and institutions throughout the state.

William Davis Brackett's papers relating to his service in eastern North Carolina with E Company of the 45th Massachusetts Infantry Regiment during the Civil War, 1862-1863.

Papers of Robert Penn Warren (1885-2008 [Bulk: 1940-1989], undated) documenting the life and literary career of the noted Guthrie, Kentucky-born American poet, novelist, playwright, biographer, and educator, who played a major role in the rise of the Fugitive and Agrarian literary movements and in the spread of the New Criticism during the mid-20th century, and who became the first poet laureate of the United States, including correspondence; manuscripts, photographic prints, proofs of published materials, printed material, loose manuscript items from the Stuart Wright Book Collection, audio recordings and oversized materials, by or about Robert Penn Warren, Cleanth Brooks, John Ciardi, Annie Dillard, Fred Chappell, Richard Ghormley Eberhart, Robert Frost, George Garrett, Randall Jarrell, Robert Lowell, Bernard Malamud, Albert J. Montesi, John Crowe Ransom, Theodore Roethke, William Carlos Williams, and others; in English, Dutch, and Latin language.

The papers consist mainly of correspondence, North Carolina Medical Society presidential address and gavel, playbill and study guide, curriculum vitae, photographs, and newspaper articles.

Diary (1864-1865) kept by William W. Perry, a Pennsylvania soldier who joined the Union Army on January 4, 1864, at the age of thirteen. Also included are eight pages listing the men from Ringgold, Pennsylvania, who served in the Union Army during the Civil War.

Papers of Mary Eloise von Schrader Jarrell (1965-2012, undated) documenting the life and literary career the St. Louis, Missouri-born, memoirist and patron of the arts, who was the widow and literary executor of poet and educator Randall Jarrell (1914-1965) consisting of correspondence with Stuart Wright, typescripts, loose manuscript items transferred from the Stuart Wright Book Collection, printed materials, and oversized materials relating primarily to her life with Randall Jarrell and the promotion of his works and literary influence on American poetry.

This collection contains Alliance magazine, which provides information on faculty, staff, student, and curriculum news and provides information on conferences and events sponsored by the School of Allied Health.

Collection (1837-1985, undated) including photocopies of correspondence, deeds, receipts, statements, ledgers, bills of lading, license, reports, bulletins, genealogical, retail merchandising, letters etc.

Collection contains newsletters produced by Joyner Library at East Carolina University.

Papers of ECU professor and writer Vernon A. Ward, Jr. containing his published works, literary manuscripts, poetry drafts, correspondence, clippings, memorabilla, and photos.

This collection contains Pulse, which relays updates on the School of Nursing.

Papers (1921-2002) musical scores, published sheet music and lyrics, biographical articles, contracts, LPs, cassettes, videotapes, reel to reel tapes, compact discs, clippings and photographs pertaining to noted North Carolinian Loonis R. McGlohon's career as a musical composer, arranger, orchestra leader and performer of jazz, popular and sacred music. Many items also relate to McGlohon's personal life such as photographs, reel to reel tapes of family events, passports, deeds, wills, death and birth certificates, military discharge papers and correspondence with well-known musicians, actors and political figures.