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Personal files (1939-1989), related to Leo Warren Jenkins outside of his positions at East Carolina University (and when it was called East Carolina College), including correspondence, clippings, reports, a manuscript, photographs, ephemera, programs, and U.S. Marine Corps documents and WWII service medals.

Lemuel Showell Blades, III, (1933-2011) began his career as a lawyer and then went on to become the president of the Norfolk Telephone Company while serving on a number of committees in Elizabeth City, and New Bern, North Carolina. This collection spans from 1711-2011 and includes newspaper clippings, photographs, genealogical charts, letters, oral histories, books, videos, and career files. The strength of this collection is the genealogical overview of the several generations linking to the Blades family.

Papers (1935-2008, undated) pertaining to noted North Carolina-born poet, educator and artist, A. R. [Archie Randolph] Ammons (1926-2001), including manuscripts, books, proofs, broadsides, pamphlets, periodicals and original art by, about, or owned by Ammons; and relating to his family and childhood, near Whiteville, NC, his service in the US Navy on a destroyer escort 1942-1945; his attendance at Wake Forest University (BA, 1949) and University of California, Berkeley (MA, 1951); his career as teacher and principal at Hatteras Elementary School, as an editor, and as an executive at his father-in-law's glass manufacturing company in New Jersey; but primarily relating to his life as a poet and his academic career at Cornell University, 1964-1998, where he was Goldwin Smith Professor of Poetry at Cornell University after 1989; and to his numerous published works of poetry and his two National Book Awards (1973 and 1993) among other prizes.

Diaries, journals and letters (1897-1906, 1986-1988) of Mormon missionaries in Eastern North Carolina (1897-1906), including William A. Adams, 1900-1902, James Godfrey, 1899-1901, William M. Hansen, 1897-1898, William R. Hobbs, 1901-1903, Lewis Johnson, 1903-1905, William A. Petty, 1905-1906, and James Taylor, 1900-1902, along with Memoirs, Notes, clippings, anecdotes and other materials compiled by Joel Grant Handcock, for use in the book Strengthened by the Storm.

Records (1966-2006, undated) documenting the activities of the League of Women Voters of Pitt County, North Carolina, a women's political organization, including historical materials, board of trustees files, publications, clippings, research files, membership files, financial records, scrapbooks, oversized materials, correspondence, annual reports, photographic prints and slides, bylaws, and position statements.

The U.S. Navy Memorial Foundation Collection: Lee D. Teal Papers contains materials documenting service aboard two U.S. Navy escort carriers during World War II: the USS Kitkun Bay (CVE-71) and the USS Hollandia (CVE-97). Items include a narrative history of the Kitkun Bay with an accompanying photograph of Lee D. Teal (1943–1945) and a program from a Divine Worship Service held aboard the Hollandia in 1944.

This collection contains the written works of Dr. Henry Merritt Stenhouse, a U.S. Naval doctor. The written works detail his life as a naval doctor while in China and Japan (1918) and thoughts towards the Russian Revolution, the Chinese revolution, and their culture. It also gives detailed accounts of some illnesses, diseases, and injuries treated by Dr. Henry Stenhouse as well as his life as a medical student at the University of Colorado.

Papers (1910-1956, undated) of U. S. naval officer, graduate of the U. S. Naval Academy, 1912, who was executive officer aboard the USS FANNING when it sank a German U-Boat U-58 during World War I, and during World War II commanded the battleship USS NORTH CAROLINA in the South Pacific, consisting of correspondence, battle reports, reports, speeches, Naval War College papers, citations, publications, newspaper clippings, photographs and miscellaneous.

Papers (1918-1957) including personal letters, correspondence, official naval orders, certificate of award and promotion, photographs, biographical sketches, etc.

The collection includes publications created by the ECU School of Medicine and the University Health Systems of Eastern Carolina, formerly Pitt County Memorial Hospital.

Records (1886-1939) and histories (1908, 1971-1973) of Goshen Missionary Baptist Church in Brunswick County, North Carolina.

Papers (1889-1945) including correspondence, birth books, land records, financial records, ledgers, report cards, advertisements, etc.

Information and artifacts from the visits to Laupus Library by librarians from the Moldovan Scientific Medical Library in 2007 and by the Moldovan Minister of Health in 2008.