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Papers (1942-1947) include correspondence related to the World War II U.S. Navy careers of Frank A. Bartimo and his brother-in-law Richard Toomey, and Bartimo's civilian life with the Army's Judge Advocate section stationed in post-war Heidelberg, Germany.

This collection contains documents (1821-1994, bulk 1860s-1910s) related to the Newsom family, especially Marion Eaton Newsom, of Littleton, Warren and Halifax Counties, North Carolina. Included are correspondence, land records, legal records, financial papers, and a family history written by Marion E. Newsom (1909, addendum 1911) about the Newsom and Nicholson families. Some material also relates to the Whitaker and Heptinstall families. A large part of this collection also documents the history of Littleton and institutions there such as schools, churches, and Littleton Female College.

Album (1922, 1939, 1942, undated) of photographic prints taken by an unidentified seaman, aboard the American armed merchant vessel SS HAGOOD, mostly during its voyages across the North Atlantic and North Sea to Great Britain during the period of October – December 1942 during World War II.

This collection contains minutes from several eastern North Carolina Primitive Baptist churches including Mill Branch (1882-1998) and Nashville (1896-1983) churches in Nash County, Briery Swamp Church (1991-2006), and Kehukee (1971-1994) and Contentnea (October 1985) Primitive Baptist Associations. Other records include expense accounts and correspondence for Mill Branch Church; Bible records for the Barnhill family; correspondence and publications relating to a schism (1979) between Elder David Spangler and Brethren Eldon Gilbert and St. Clair Graham of Ontario, Canada; forms and clippings related to the Norfolk and Briery Creek Associations; and miscellaneous items.

Papers (1861-1946, undated) consisting of correspondence, Indian reservation schools in Oklahoma, legal records, receipts, poetry, receipts, poetry, handwritten history, blueprint.

Collection (1760-1940) including land grants, deeds, bill of sale of enslaved persons, correspondence, Civil War documents, and an account book, pertaining to the land holdings and genealogy of the McIver, McLeod, Lane, Crawford, Mumford, and Faison families of Moore, Chatham and Columbus counties, North Carolina.

Collection (1852-2014) includes correspondence, newspaper clippings, printed materials, and other items compiled by retired East Carolina University English professor emeritus Dr. Ralph Hardee Rives (1930-2016) relating primarily to the Hardee - Rives and related families of North Carolina and the United Kingdom, the history of Eastern North Carolina (especially Halifax County and the town of Enfield), the United Methodist Church in Eastern North Carolina, state and local and national politics, and his charitable and philanthropic interests. The earliest original documents cover the period from 1852 through the Civil War and World War I.

Papers (1943–1945) including copies of correspondence, personal notations, orders, addresses, photographs, reminiscences, equipment lists, and reports pertaining to his World War II service with the 14th Malaria Control Unit of the U.S. Army Air Corps in New Guinea and the Philippines, 1943–1945, including references to malaria control, military issues, and incidents involving Japanese, American and Filipino forces.

This collection contains a single Civil War Diary (October 1, 1862 - March 24, 1863) kept by William H. H. Leach.

Papers (1945-1984 [Bulk: 1984]) documenting the life and literary career of Karl [Jay] Shapiro (1913-2000), the noted Baltimore, Maryland-born American poet, critic, and educator, consisting of an unbound page proof of Love and War, Art and War (1984) by Karl Shapiro; also containing loose manuscript items transferred from the Stuart Wright Book Collection relating to Collected Poems, 1940-1979 (1945-1984), New and Selected Poems (1984), and To Abolish Children and Other Essays (1984) by Karl Shapiro.

This collection contains the written works of Dr. Henry Merritt Stenhouse, a U.S. Naval doctor. The written works detail his life as a naval doctor while in China and Japan (1918) and thoughts towards the Russian Revolution, the Chinese revolution, and their culture. It also gives detailed accounts of some illnesses, diseases, and injuries treated by Dr. Henry Stenhouse as well as his life as a medical student at the University of Colorado.

The C. B. West collection consists of a ledger documenting construction projects of C. B. West and his son in Greenville and other cities; and materials purchased from such suppliers as W. H. Dail of Greenville; and three Greenville Mayor's Court record books documenting minor crimes in Greenville.

Collection of photographic materials dating from 1944 to 1974 created by Dr. Samuel T. White, II, a Greenville, North Carolina optometrist. Materials include photographic prints, negatives, slides, indexes, and printed forms documenting personal, professional, and artistic photography. Subjects include portraits of family and acquaintances as well as landscape and community scenes primarily depicting Eastern North Carolina. An additional group of forty five black and white photographic prints is also included.

This collection includes many letters written during the American Civil War by Dr. Charles James O'Hagan, an Irish immigrant who settled in Pitt County, North Carolina, and served in the North Carolina State Troops as a surgeon, to his daughters; and letters written by Confederate soldiers to his eldest daughter. Also included are letters (1840s) from family in Ireland and testamonials written to help Dr. O'Hagan find employment; letters written in the post-Civil War era 1860s through 1882; and letters, photographs, and obituaries concerning the related Laughinghouse and Grimes families of Pitt County, N.C., in the late 19th century and early 20th century.

Isabel Sue Nelson was born on January 30, 1914 in Littleton, North Carolina. She worked in Washington, North Carolina and the Office of Warren County, North Carolina Clerk of the Court. The Collection spans 1894-2008 and includes correspondences, photographs, and newspaper articles. The strength of the collection is documents relating to Littleton, North Carolina Female College Students.