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The Neyuherú·kęʼ Wampum Belt tells a story of the Tuscarora Nation's experience in North Carolina and New York. It is sacred to the Tuscarora people. The Neyuherú·kęʼ Wampum Belt was presented to the "people of North Carolina" and accepted by then Provost Marilyn Sheerer and ECU on behalf of North Carolina in 2013 to commemorate the 300th anniversary of the Neyuherú·kęʼ Battle. Alternate spellings are Noherooka and Neoheroka.

Collection includes two folders of 48 items primarily of correspondence, letters and financial documents for a transport business that shipped commodities by riverboat.

Papers, 1937-2001, of U. S. naval officer, including diaries, scrapbooks, orders, photographs, biographical accounts, and other materials, compiled by Commander Charles P. Trumbull (USN ret.), documenting his naval career from his appointment to the U. S. Naval Academy at Annapolis, MD, as a member of the Class of 1941 to his retirement from the Navy in 1961, and his post-retirement life, 1937-2001.

Ten handwritten letters between William J. Blow and W. J. Marsh and handwritten transcriptions. This exchange of letters was about W. J. Marsh [or W. T. Marsh] "demanding satisfaction for offensive language used by Dr. Blow" towards him.

Collection (1763-2013) including correspondence, financial records, legal records, clippings, land records, photographs, clippings, poetry, genealogy and miscellaneous files compiled by William L. Murphy related to genealogy research in Eastern North Carolina.

Papers of Robert Penn Warren (1885-2008 [Bulk: 1940-1989], undated) documenting the life and literary career of the noted Guthrie, Kentucky-born American poet, novelist, playwright, biographer, and educator, who played a major role in the rise of the Fugitive and Agrarian literary movements and in the spread of the New Criticism during the mid-20th century, and who became the first poet laureate of the United States, including correspondence; manuscripts, photographic prints, proofs of published materials, printed material, loose manuscript items from the Stuart Wright Book Collection, audio recordings and oversized materials, by or about Robert Penn Warren, Cleanth Brooks, John Ciardi, Annie Dillard, Fred Chappell, Richard Ghormley Eberhart, Robert Frost, George Garrett, Randall Jarrell, Robert Lowell, Bernard Malamud, Albert J. Montesi, John Crowe Ransom, Theodore Roethke, William Carlos Williams, and others; in English, Dutch, and Latin language.

Papers of Mark Smith (1967-1971) documenting the life and literary career of the noted Michigan-born American novelist and professor of English at the University of New Hampshire; consisting of a bound, paperback, proof of his novel The Middleman (1967); also an oversized periodical entitled Invisible City (1971).

Papers (1766-1869) consisting of correspondence, legal papers, land records, financial papers, reports, newspapers, and miscellaneous items.

Papers (1947-1960) including correspondence, references concern Bible, auditing of books, school events, receipts, pilgrims, and miscellaneous.

Papers (1891-1905) consisting of correspondence; comments; inquiries; letters on flora, romance, religion and inquiries; postcards, business cards.

Joseph Hewes, William Hooper, and John Penn signed the Declaration of Independence in Philadelphia, Pennsylvania on July 4, 1776. All three men were delegates of North Carolina at varying times between 1774-1777. The collection spans 1925-1926 and includes two photographic prints and two letter correspondence. The strength of the collection are the photographic prints of two of the three North Carolina Declaration of Independence Signers and biographical notes.

Papers (1925-1978) consisting of a diary, copy of a manuscript, bulletins, newsletters, photographs, and miscellaneous material.

Papers (1852-1864) including correspondence, letters, description of trip, commentaries, price of gold, personal illness, etc.

In 1972, Evelyn McNeill was offered a position as an assistant professor of anatomy at East Carolina University School of Medicine (renamed Brody School of Medicine in 1999). She was hired to teach neuroanatomy to medical students as well as physical and occupational therapy students. During her career at the medical school (1972-2001), Evelyn opened her home to students. She began traditions of hosting an end-of-first-year party and another for Halloween. Included in this collection are personal photographs from these parties, historical photographs of the growth and development of the school of medicine, newspaper clippings of medical student announcements, and medical school class photos and rosters during the period of 1972 to 2004.

Slides, posters, photographs, publications, and other memorablia of Dr. William H. Waugh.