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Collection (12 February 1864) consisting of a letter from Pvt. James Addison Lowrie, Company D of the 57th North Carolina Infantry, at Kinston, NC, to his brother Robert [of Brunswick County, NC], reporting on his good health, the poor mail service, the lack of news, the growing dissatisfaction among "the boys", the recent desertion of 14 men from the 21st Regiment North Carolina Infantry, and the Kinston Hangings, the hanging, on 12 February 1864, of five men who had deserted the Confederate Army and been recaptured: Amos Amyett, Mitchell Busick, Lewis Bryan, William Irving and John Staley; after deserting, the men had joined the 2nd North Carolina Union Volunteers and been captured on 1 February 1864, at Beech Grove; also transcript of letter; also digital copy.

Commonplace book (1801-1846) compiled by G. Harris, while surgeon aboard a British East India Company opium-carrying ship, the 750 ton Lady Flora, just off Singapore, wherein he documents his care of two patients, a comatose 6-year old boy suffering from fever, and a 30 year old woman who was hemorrhaging; lists of more than forty books; abstracts from them including medical titles such as "Diseases of the East Indies," "Johnstone on Diseases of Hot Climates," "Jenner on Vaccine Inoculation," Erasmus Darwin's "Zoonomia...," Burke's "Essay on the Sublime," and "Southey's Life of Nelson"; including an engraved stationer's seal from I. W. Norie and Co. on the front pastedown; a "A New and Correct Plan of the City of Bath, published in 1801, and a several loose notes.

This collection primarily contains physical and digital photographs of descendants of Willie Brown (1799-1867) and Nancy Moye Brown of Greenville and Pitt County, North Carolina, especially through the line of their son Dr. William Moye Benjamin Brown (1823-1903) and his wife Jane Marie Greene.

Joseph Hewes, William Hooper, and John Penn signed the Declaration of Independence in Philadelphia, Pennsylvania on July 4, 1776. All three men were delegates of North Carolina at varying times between 1774-1777. The collection spans 1925-1926 and includes two photographic prints and two letter correspondence. The strength of the collection are the photographic prints of two of the three North Carolina Declaration of Independence Signers and biographical notes.

Papers (1939-1995, 2007) including McDaniel family and Harvey family genealogical research; and U.S. Air Force Flying Status Files and related files (1942-1980), recording Linton's military career. These files document his career including the U. S. Military Academy Class of 1942, his pilot training and World War II service in the 5th Air Force in the Pacific, and his postwar service in Germany with the 12th Air Force, and the 601st Aircraft Control and Warning Squadron and 526th Tactical Control Group. Also documented are his service in the U.S. Air Force Reserve, his continuing education courses, and his retirement.

The collection contains the records of the East Carolina Faculty Wives Club, later known as the East Carolina University Women's Club and the East Carolina University Club.

This collection contains administrative records, committee minutes and records, materials pertaining to events and programs sponsored by the Student Union, and records that pertain to the construction and renovation of Mendenhall Student Center and Wright Auditorium.

Papers (1911-1945) including correspondence of Bogue Banks, dairy farm, letters commentary, social activities, republican committee, financial papers, manuscripts, pamphlets, blue prints, etc.

Collection (1782) consisting of land grant patent.

The Edwin Monroe Papers include reports, correspondence, speeches and statements, newspaper clippings, ephemera, and photographs related to the ECU medical school.

Records (1943–1946) of the escort ship USS Hopping (DE-155), attached to Escort Division 6 of the Atlantic Fleet during World War II and including war diaries, action reports, and miscellaneous material relating to U-Boat attacks, anti-submarine warfare, etc.

Collection (1852-1945) including correspondence, legal papers, copies of speeches, a diary, a map, etc., relating to the political careers of Charles W. McClammy and his son Herbert McClammy, who served as US congressman (D-NC).

Collection (1863-1865) related to the American Civil War and Andrew Giddings of Company E, 3rd North Carolina infantry. Includes Oath of Allegiance to the United States signed by Andrew Giddings on November 6, 1865 [Following the American Civil War, Confederate officials, veterans and prisoners of war were obliged to sign an "oath of allegiance" to regain their civil rights under the U. S. Constitution.]. The collection also includes a note concerning the capture of Washington Rose, a member of Company C, 6th Louisiana Regiment at the Battle of the Wilderness. Most significantly, the collection contains Andrew Giddings' leather-bound diary and ledger of income and expenses, which includes eyewitness accounts of the engagements in which he participated, including Gettysburg, Cold Harbor, Sharpsburg, Malvern Hill, 2nd Winchester, Chancellorsville, and Wilderness. It also includes descriptions of his capture and imprisonment in a Union prisoner of war camp. The collection also includes an envelope that held the diary with "Granddad Giddings Diary" written on it.

Collection (1922-1948), including PTA minutes, bulletins, charter and building specifications.