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Collection (1816-1899) including correspondence, legal papers, military papers, etc. relating to William D. Holt and his cotton sales business, local policies, railroad construction, the Farmers Alliance, private debts, his service during the Civil War, and business records.

The Ethel Clements Sherrod Collection contains personal papers of Ethel Clements Sherrod, including biographical material, correspondence, photographs, clippings, ephemera, printed items, nursing school notes, postcards, and choral music. Materials date from 1777 to 1987, with the bulk between 1920 and 1970, and document Sherrod's education, church and choir participation, family life, and community activities. Additional materials relate to members of the Sherrod family and to associates including Dr. Ralph Hardee Rives, Hazel Odell Holt, and L. R. Shepherd.

Papers (1943–1945) including copies of correspondence, personal notations, orders, addresses, photographs, reminiscences, equipment lists, and reports pertaining to his World War II service with the 14th Malaria Control Unit of the U.S. Army Air Corps in New Guinea and the Philippines, 1943–1945, including references to malaria control, military issues, and incidents involving Japanese, American and Filipino forces.

Collection (1911-1956, bulk 1918-1919) consists of material related to Roy S. Fisk who served as an Army cook with Co. C, 131st Engineers, AEF, stationed in Le Mans, France, during the latter half of World War I. Included are correspondence, papers related to Fisk's military career, war-related publications, French guide books and souvenir photo albums from places he visited in France, a postcard book from the USS Kaiserin Auguste Victoria, and Vol. 1, No. 19, April 10, 1919, issue of The Bulletin which discusses issues in France and the military career of Brigadier General George S. Simonds. Also included are some papers and ephemera related to his post-military life.

Papers (1925-1978) consisting of a diary, copy of a manuscript, bulletins, newsletters, photographs, and miscellaneous material.

Papers (1830-1931) including correspondence, speeches, property records, deeds, appointments, clippings, financial records, etc. of a Quaker farmer and business leader in Belvedere (NC).

Papers (1929-1974) of Rear Admiral Wilson Durward Leggett, Jr., U.S. Naval Academy graduate of 1920 and Tarboro, North Carolina, native, including correspondence, photographs and photograph album, newspaper clippings, an order book, newsletters, journals, scrapbook, etc., documenting his Naval career and work with Rensselaer Polytechnic Institute School of Science and the Joint Committee on Atomic Energy.

This collection contains a single Civil War Diary (October 1, 1862 - March 24, 1863) kept by William H. H. Leach.

This collection contains 539 letters (1943-1945) written by Jack Ladd Carr (1924-2010) to his family in Pennsylvania while he was stationed in Fort Jackson (South Carolina) for basic training, in Camp San Luis Obispo and Camp Pendleton in California, and the Pacific Theatre during World War II. Carr joined the U.S. Army in March 1943 and returned to the United States in December of 1945. He was involved in attacks on Anguar Island and took part in Operation Forager.

Collection including correspondence, legal papers, photographs, newspapers, etc. relating to the North Carolina Shipbuilding Company, and the construction of "Liberty Ships" during World War II.

This collection contains letters, clippings, photographs, and historical information about Vanceboro, North Carolina.

Papers of Cleanth Brooks (1951-1986) documenting the life and literary career of the noted Murray, Kentucky-born American editor, literary critic and educator at Yale University, who was influential in the New Criticism movement as editor of The Southern Review, 1935-1942; consisting of loose manuscript items transferred from the Stuart Wright Book Collection, including Brooks' signed contract to sell his books and literary periodicals to Stuart Wright correspondence between Brooks, George Garrett Stuart Wright; also a reprint of Milton and the New Criticism, by Cleanth Brooks (1951).

This collection contains records of Eric G. Flannagan & Sons architectural firm that relate to capital projects on the East Carolina campus.

The collection includes correspondence, minutes, programs, lists, dues information, journal reprints and articles, newsletters, receipts, clippings, reports, and photographs. Addition of January 2017 includes programs, newsletters, photographs, books, articles, clippings, deceased members files, Country Doctor Museum and East Carolina University alliance, and transcription project of the Country Doctor Museum oral histories.