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Papers (mostly 1911-1958) consisting of correspondence, clippings, newspapers and photographs related to [Eleazer] Van Ness Harwood, Jr.'s career as a newspaper reporter, especially with The World in New York City (1899-1925), and as a publicist for people such as Mme. Marie Curie, and to his family life. Major topics documented are the Wright Brothers' 1911 flights at Kitty Hawk, N.C., and a visit by Mme. Curie to the United States in 1929 to receive a gift of one gram of radium for use in scientific research.

Papers of Nancy [Anna Westcott] Hale (1971) documenting the life and literary career of the noted Boston, Massachusetts-born journalist, novelist, playwright, and artist; consisting of an unbound, oversized, galley proof of her novel Secrets (1971).

Correspondence, notes, a family history, and other genealogical materials of Col. David L. Hardee pertaining to the Hardee-Hardy families.

The U.S. Navy Memorial Foundation Collection: Lee D. Teal Papers contains materials documenting service aboard two U.S. Navy escort carriers during World War II: the USS Kitkun Bay (CVE-71) and the USS Hollandia (CVE-97). Items include a narrative history of the Kitkun Bay with an accompanying photograph of Lee D. Teal (1943–1945) and a program from a Divine Worship Service held aboard the Hollandia in 1944.

Collection consists of copies of the Mellette Family History, and a History of Pleasant Hill Masonic Lodge, No. 304.

Papers of Cleanth Brooks (1951-1986) documenting the life and literary career of the noted Murray, Kentucky-born American editor, literary critic and educator at Yale University, who was influential in the New Criticism movement as editor of The Southern Review, 1935-1942; consisting of loose manuscript items transferred from the Stuart Wright Book Collection, including Brooks' signed contract to sell his books and literary periodicals to Stuart Wright correspondence between Brooks, George Garrett Stuart Wright; also a reprint of Milton and the New Criticism, by Cleanth Brooks (1951).

Collection (1943-1945) of member of U.S. Naval Academy Class of 1941, including correspondence, typescript diary relating to the cruise of the USS BORUM (DE-790).

This collection (1880s-1980s) concerns the Holt family of Smithfield in Johnston County, North Carolina, and the Henderson family in Conecuh County, Alabama, and the Wilson family of Harrison and Detroit, Michigan who are related through marriage. The Holt family material mainly concerns William and Nancy Holt and their children and includes correspondence, diaries, school records, 16 mm films, photographs, and documents such as oil and gas leases in Texas related to William's work with The Texas Company (part of Texaco). The larger portion of the material is related to the other two families and includes correspondence, photographs (tintypes through color snapshots), ledger books and deeds (many related to timber purchases in Alabama and Michigan), and undated plat books for Michigan.

Papers of Fred Chappell (1952-2017, undated) documenting the life and literary career of the noted Canton, North Carolina-born American educator, short story writer, novelist, and educator, whose writing focus on Southern themes, consisting of correspondence, holographs, typescripts, loose manuscript items transferred from the Stuart Wright Book Collection, photographic prints, proofs of published works, audio recordings, printed materials & oversized materials; also including Chappell's correspondence with George Garrett, Stuart Wright and Wallace Fowlie, a clipping and a print of his poem The Collector (2011) written in honor of Stuart Wright, and a painting by Fritz Janschka.

Artwork and prints, primarily oversized, found in Country Doctor Museum items. Includes prints from "A History of Pharmacy in Pictures," "A History of Medicine in Pictures," "History of Anesthesia in Pictures," "Gay Philosopher" by Henry Major, "Pioneers of American Medicine" by Dean Cornwell, and other prints.

Papers (1898-1946, undated) including correspondence, newspapers, notes, programs, etc. compiled by a teacher in the English Department of East Carolina Teachers Training School.

Records (1888-1968) including correspondence, legal records, reports, photographs.

The collection includes publications created by the ECU School of Medicine and the University Health Systems of Eastern Carolina, formerly Pitt County Memorial Hospital.

Papers of William Goyen (1935-1999, undated) documenting the life and literary career of the noted Trinity, Texas-born, American novelist, short story writer, poet, playwright, editor and educator at several schools, including Brown University; consisting of loose manuscript items transferred from the Stuart Wright Book Collection, including manuscripts, notes and clippings by or about William Goyen, D. H. Lawrence, Merriam Golden, Stephen Spender, and others; also including printed materials.

Original material collected by Horace H. Mewborn, Jr. including printed maps, letters, diaries, clippings, cartes de visite, tintypes, an ambrotype, memoir, ledgers, reports, and drawings related to the Civil War especially pertaining to Col. John S. Mosby and his 43rd Virginia Cavalry Battalion, Col. Elijah V. White and his 35th Virginia Cavalry Battalion, North Carolina Cavalry Units, and the battles fought in the New Bern, NC, vicinity. Also included is his voluminous research related to the above listed units and the Army of Northern Virginia and the Army of the South.