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The papers track the history and development of Pitt County Memorial Hospital(previously Vidant, now ECU Health) and Brody School of Medicine, including scrapbooks, photographs, publications, and videos.

Civil War Correspondence, (1861–1863) of Union soldier George H. S. Driver, reflecting service in New Bern and Pamlico Sound area of N.C.

Papers (1705-1928) of Alamance County, North Carolina, native William L. Spoon (1862-1942) consisting of correspondence, a diary, pamphlets, almanacs, maps, photos, reports on weather, tax receipts, and land records. Spoon was a surveyor who was supervisor of public roads in Alamance County and worked as an agent of the U.S. Department of Agriculture as well as a teacher, inventor, and traveling salesman.

Papers of George Core (1960-1997 [Bulk: 1960-1983]) documenting the life and literary career of the American historian, literary critic, and editor relating to his life and career as editor of The Sewanee Review, 1973-2016, including holographs, typescripts and other manuscript materials; photographic prints; loose manuscript items transferred from the Stuart Wright Book Collection, including correspondence with Donald Davidson, Stuart Wright and Durrett Wagner of Swallowtail Press; a photograph of George Core at The Sewanee Review; a note about Andrew Lytle's work The Hero With The Private Parts; and materials relating to books he reviewed, including Any Cold Jordan and Camping Out.

Papers (1805-1968; bulk 1860-1916) consisting of correspondence of a political nature, family-related correspondence, speeches, financial papers, farm records, farm account books, clippings, photographs, a diary and printed material related to Elias Carr and other members of the Carr and related families. Elias Carr (1839-1900) of Edgecombe County, a member of the Democratic Party, was the governor of North Carolina (1893-1897) and president of the N.C. State Farmers' Alliance and Industrial Union (1889-1892).

Record volumes (1877-1987, undated) including Great Swamp Primitive Baptist Church Record, 1884-1980; Record of Primitive Baptist Church at Great Swamp, 1877-1915; [Great Swamp Church] Members / Conferences, 1916-1930; and loose material removed from Garner Family Bible including letters, clippings, emphemera, and Garner family genealogical information, ca. 1878-1987, undated

Papers (1727, 1823-1896, 1924, 1947) of Martin County, NC family, including correspondence, land records, plats, mortgages, a recipe, promissory notes, summonses, account of estate sales, receipt, and miscellany.

Records (1761-1936, 1942-1981) including correspondence, legal and financial papers, estate papers, receipts, financial records, surveys, newspaper clippings, photographs, bills of lading, genealogy, stock certificates, corporation minutes, and land records.

Papers (1937-2002) including correspondence, diary, log books, newspaper clippings, military papers, photographs, identification cards and miscellaneous items related to the life of Louis Poisson Davis, Jr., a U.S. Navy Lieutenant Commander during World War II serving aboard submarines USS Salmon and the USS S-18.

Papers (1941-1945) of U.S. Naval officer, USNA Class of 1941, including an autobiographical account, a letter describing experiences aboard the USS West Virginia during the Japanese attack on Pearl Harbor, a letter explaining terms used in letters to avoid censorship, several speeches to civic organizations on his experiences during World War II and his relationsip with Admiral Hyman George Rickover.

This collection contains information on people, places, and events arranged by subject. Many items are not originals.

Papers (1826-1887, undated) including correspondence, journals, leaflets, diaries, verse, printed material, a drawing and miscellany.

Papers (1942-1945) including correspondence, picture, Christmas card, references of shortage of beer and cigarettes.

Papers (1953-1991) of USAR officer, system engineer, and senior logistics analyst, including correspondence, a diary (1969-1976), photo albums, clippings, and miscellaneous materials.

Papers, certificates, photos, and artifacts of Dr. Edwin Wall Monroe. This collection contains a great deal of information regarding the development of the East Carolina School of Medicine, including planning, politics, legislation, advertisement, construction, partnerships, details of the personnel involved, groundbreakings and other ceremonies, departments, additional buildings, and community services.