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Letter (June 22–23, 1840) from John and M. J. Atkins of Averasboro, North Carolina, to their cousin Caroline E. Turner in Montgomery, Alabama. The writers discuss family news, domestic activities such as dressmaking and preserving, local economic "hard times," and mention a forthcoming Whig political meeting in Averasboro.

Tales of the Tobacco Country, by Thomas A. Williams; bound at the author's expense (July 1977). The collection also contains photographic prints, circa 1925, depicting Greenville, North Carolina, local businesses, street scenes, and other unidentified locations that appear to have been used as reference material during the preparation of the publication.

This collection (1821-2007) contains several groups of family history-related papers concerning eastern North Carolina and a large number of unrelated miscellaneous items such as photographs, church records, Bible records, and rare printed items on a variety of subjects. The majority of the family papers concern the Croom and Whitfield families of Lenoir County, N.C. Other family papers concern the Harvey family of Greene County, N.C., the Jordan and Waters families of Washington, N.C., the Meeks family of Pitt County, the Outlaw family of Lenoir County and the Thompson family of Georgia. A large part of this collection concerns the Ficklen family of Greenville, N.C., including scrapbooks, diaries, an autograph book and a post card collection. Some items concern the colorful poet, magazine editor, railroad speculator, paper mill owner, Civil War blockade-runner, and sea captain Appleton Oaksmith who lived in Carteret County, N.C., for fifteen years (1872-1887). Also included are ambrotype photographs of Confederate Civil War soldiers James Needham Alexander, who served in Company A, 11th North Carolina Troops (Infantry) and Stanhope Washington Alexander, who served in Company H, 35th North Carolina Regiment.

This collection contains postcards related to East Carolina.

This collection contains papers and ephemera (1875-1985) pertaining to the Barnes Family of Murfreesboro, North Carolina, and the surrounding area. Included are correspondence, land records, photographs, genealogy notes, wills, obituaries, programs, autograph book (1884), report cards from Wesleyan Female College and UNC Chapel Hill, poetry, and accounts.

Collection (1839-1976) including correspondence, receipts, legal papers, poems, military orders, list of patients, etc., related to Nash and Franklin counties, North Carolina, and a scrapbook tracing the activities of Miss Minnie B. Parker as a nurse for the American Expeditionary Force in France, during World War I (1918-1920).

A collection (ca. 1885-1918, undated) of 55 cartes de visite and cabinet cards mounted on cardboard, a scrapbook containing 11 snapshots, a manuscript, and printed materials belonging to John Miller Faison, a North Carolina physician, Democratic Party leader, and Congressman from the N.C. Third District between 1911 and 1915.

Oral history interview with prominent African American businessman and political leader of Greenville, North Carolina, named Denison D. "D.D." Garrett, Sr. He discusses his background, education, business pursuits, and political involvement including race relations in Greenville and Pitt County, especially during the Civil Rights era.

Papers (1918, 1932, 1942-1969) of Episcopalian missionary from Elizabeth City, North Carolina, to the Philippines including correspondence, financial records, affidavits, typescripts, newspapers, and miscellany. A lot of the documentation pertains to her time in the Los Banos Internment Camp during the Japanese occupation of the Philippines during World War II.

This collection (1966-2011) consists of papers, ephemera, and printed oversize materials related to Democratic and Republican party politics in North Carolina that document elections and Chester Julian (C.J.) Hyatt's involvement in politics. There is also material related to George C. Wallace's campaign for president in 1968, 1972, and 1976. Hyatt was state chairman for Wallace's run in 1976.

This collection contains materials of alumnus Margaret Frances Brake from her time as a student at East Carolina College. Many items relate to graduation.

Personal files (1939-1989), related to Leo Warren Jenkins outside of his positions at East Carolina University (and when it was called East Carolina College), including correspondence, clippings, reports, a manuscript, photographs, ephemera, programs, and U.S. Marine Corps documents and WWII service medals.

Collection consists of publications, newsletters, and annual reports outlining the operations of the Brody School of Medicine at East Carolina Univeristy.

This collection contains over 100 letters (1885, 1892-1897) written to Sallie Dromgoole Cotten (1876-1972), daughter of Sallie Swepson Southall Cotten and Robert Randolph Cotten, either while she was at home at Cottendale in Falkland, Pitt County, North Carolina, or at Notre Dame of Maryland Preparatory School and Collegiate Institute in Baltimore. The letters are written mainly by Sallie's female friends, but also some male friends in the 1890s (1892-1897) The correspondents are family, associates, and friends, especially schoolmates. Topics are mainly related to interests of college women and men. Also included are ephemera such as dance cards and dance invitations especially to "German" dances which were large popular events among wealthy white families in Eastern North Carolina tobacco towns in the 1890s.

Collection contains mainly material related to the African American Navy Band members who served at the Great Lakes Naval Base during World War II (1942-1945). This material includes programs and related material from the February 28-March 2, 2003, salute to these African American band members that was held in Chicago, Illinois, and from former band member Carl Foster's participation in a symposium sponsored by the North Carolina Museum of History in 2003. Other material includes programs (1987) for concerts by the North Carolina Jazz Ensemble and a 1945 USO Hawaii booklet. A second focus of this collection is on the lives of Alex Albright's family members including uncles on his mother's side and their involvement with the CCC (Civilian Conservation Corps) and World War II service and death.