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Contained in this collection are materials originally owned by Dr. William C. Groves including medical lecture tickets from Pennsylvania College and a patient's death certificate.

Records (1804-1926) of Pitt County, NC Family, including birth and death records, deeds, petitions, and a plat for property in the flat swamp area, including Oak Grove Church and Academy.

Civil War Correspondence, (1861–1863) of Union soldier George H. S. Driver, reflecting service in New Bern and Pamlico Sound area of N.C.

Papers (1917-1941) of Frank M. Wooten Sr. (1875-1941), a leading Greenville attorney, Superior Court judge, and member of the N.C. General Assembly, and Greenville mayor, consisting of correspondence during first World War, letters, political campaign, pamphlets concerning tobacco, cultivation, agricultural alcohol, clipping, financial papers, etc.

Records (1987-2004) of the North Carolina Chapter of the Sierra Club pertaining to conservation issues in North Carolina, including correspondence, reports, directories, newsletters, financial records, membership and staff records, meeting agendas and minutes, printed materials, etc.

A collection that contains 57 diaries kept by Edward Dunham Robie (1831-1911) who was a naval engineer, inventor and a U.S. naval officer during the American Civil War.

Professional and personal correspondence, newspaper clippings, press releases, reports, and miscellany for the period 1944 through 2011, bulk dates 1962 to 1982, related to the career of Janice Hardison Faulkner at East Carolina University, with the Democratic Party in North Carolina and as the holder of several high level positions in North Carolina government.

This collection contains over 100 letters (1885, 1892-1897) written to Sallie Dromgoole Cotten (1876-1972), daughter of Sallie Swepson Southall Cotten and Robert Randolph Cotten, either while she was at home at Cottendale in Falkland, Pitt County, North Carolina, or at Notre Dame of Maryland Preparatory School and Collegiate Institute in Baltimore. The letters are written mainly by Sallie's female friends, but also some male friends in the 1890s (1892-1897) The correspondents are family, associates, and friends, especially schoolmates. Topics are mainly related to interests of college women and men. Also included are ephemera such as dance cards and dance invitations especially to "German" dances which were large popular events among wealthy white families in Eastern North Carolina tobacco towns in the 1890s.

Papers (1942–1948) including naval campaign file for Solomon Island, photographs, citations, pamphlets, battle, pictures.

Papers of Reynolds Price (1853-1986 [Bulk: 1978-1986]) documenting the life and literary career of the prolific Macon, North Carolina-born American poet, novelist, dramatist, essayist, and educator at Duke University; consisting of manuscripts, loose manuscripts transferred from the Stuart Wright Book Collection relating mainly to his publications A Common Room (1954), Mustian (1983), Private Contentment (1984), and to Reynolds Price: A Bibliography, 1949-1984 (1986), compiled by Stuart Wright; also photographic prints; proofs of works Price reviewed for publishers; and printed materials and oversized materials.

Complete 45 print series of "A History of Medicine in Pictures" produced by Parke, Davis & Company.

Papers (1926-1953) of Brig. General Paul A. Putnam, U. S. Marine Corps, an aviator, who was captured at Wake Island and was a POW in Japan, 1941-1945, consisting of correspondence, diaries, a photograph, clippings, citations, orders, recipe book, copies of awards, citations, publications, newspaper articles.

This collection contains information on people, places, and events arranged by subject. Many items are not originals.

Papers (1940–1945) of a U.S. Naval Reserve medical officer, including scrapbook of clippings, photographs, correspondence, photographs, original art, and memorabilia compiled while serving in the U.S. Naval Reserve at the Toledo, Ohio naval recruiting station, 1942–1943; And letters sent to his parents Dr. and Mrs. Carroll C. English, in Louisville, Kentucky, while serving aboard USS Trathen (DD-530), 4 April 1943–5 December 1944