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Correspondence & Financial Records (ca. 1845 - 1917, undated) of merchants, shipbuilders and mercantile family from Elizabeth City and Weeksville, Pasquotank County, NC. Individuals include Woodson Bradford Fearing, Enoch Pratt Fearing, Lizzie Parker Fearing, George Fearing, Pratt Fearing, Woodruff Fearing, Emily Fearing, Emily Ramsay Commander, M. E. Fearing, Joseph Commander and Walter J. Rhode.

This collection contains materials created or collected by Donald Leggett during his work as an employee of East Carolina.

The Ormond Family Papers (ca. 1770-1925) include correspondence, land grants, financial records, school notes taken at Trinity College, pamphlets, newspaper clippings, and photographs pertaining to the Ormond and Turnage families of Dobbs, Greene and Pitt Counties, North Carolina. Considerable material pertains to State Senator Yancey T. Ormond of Greene County.

Papers (1807-1937) including correspondence, deeds, chattel mortgages, warranty mortgages, legal records, accounts, a surveyor's map, and a photograph related to the Credle and related families of Hyde County, North Carolina.

Seven engravings of University of Pennsylvania medical school faculty.

The papers track the history and development of Pitt County Memorial Hospital(previously Vidant, now ECU Health) and Brody School of Medicine, including scrapbooks, photographs, publications, and videos.

Diary written by Edward L. Williams, while serving in the United States Marine Corps, describing his voyage, aboard the USS Alaska, to the European Station under the command of Captain Samuel "Powhatan" and under the direct supervision of Captain W. R. Brown, including their cruise along the Italian coast , frequent port calls, shipboard life, behavior of sailors, and his friendships and acquaintances among the ship's crew.

Papers (1960-1984) of Democratic political leader and governor of North Carolina, including his 1976 campaign financial records and his 1980 gubernatorial general campaign files.

Papers (1894-1901, 1958-1974, 2009, undated) of a U. S. naval officer (Rear Admiral), graduate of the U. S. Naval Academy, 1872, who served as commander of the European Squadron, 1895, and Mare Island Navy Yard, 1898, and consisting of correspondence, newspaper clippings, genealogical tables, a poem, photographs, and miscellaneous.

Collection (1823-1853) including deeds, a will, and an account book.

Collection contains a variety of items relating to Eastern North Carolina especially including a photograph of East Carolina Teacher's College scene (ca. 1940's); a theater Program (ca. 1933/34) for a play presented by The Episcopal Junior Guild, Austin Building, East Carolina Teacher's College; and a Measles in Quarantine Keep Your Babies Away From Measles Broadside (4/7/1934) posted on the home of Ella Viola McGowan when she had the measles. Also included are photographs (some unidentified) of World War II era of which several pertain to military bases such as the 657th Engineer Topographic Battalion (40th Infantry Division, U.S. Army), and one is of Cecil May in U.S. Marine corporal uniform; a photocopy of a letter (1913) containing reminiscences of Confederate veteran John W. Vernelson (of N.C. State Troops) war service and describing the Veterans Reunion at Gettysburg, PA; receipts (1909-1910) for sales by Crown Bottling Works in New Bern, NC; Pitt County, NC, land grants and deeds (1782-1837) related to the Boyd, Edwards, and Nobles families; Bible Records and birth and death records for the Eldridge, Wilder/Hatsell, Pittman, Moore, Sewell, and Davis families; and the book (2011) "One of the Lucky Ones," Edgar Cannon's Contributions in World War II. Other materials (1856-2001) consist of manuscripts, research clippings, notes, photocopies, photographic prints, programs, notebooks, and newspapers, relating to the history and genealogy of Eastern North Carolina, especially Robersonville and Williamston in Martin County, NC. Also included are a 1941 color silent 16mm film about Greenville and slides (ca. 1970) documenting tobacco and old houses in Pitt County, NC.

Memoir [1855-1867] of the author's childhood in Atlanta, GA, including Civil War and postwar references.

Vaughan Family Papers (1872-1900, 1969, undated) includes photograph albums containing images of family members from Hertford County, North Carolina. Also included is Uriah Vaughan correspondence (1876-1887) and a photocopy of the 1969 appraisal of Uriah Vaughan Heirs Property in Murfreesboro, North Carolina.