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The papers include letters, postcards, and papers written by Henderson Irwin and his father, John R. Irwin, and photographs of John Irwin's medical practice.

Papers of Willie Jordan Batts include medicinal drug recipes, typed transcription of the recipes, and "Dr. Willie Jordan Batts, Esq., Botanic Physician" by Hugh B. Johnston Jr.

This collection contains a photograph album (1944-1945) kept by Raymond Drew (of Pittsburgh, Pennsylvania) while he was a member of Marine Photographic Squadron 254 (VMD-254) during World War II. His squadron later became a part of Squadron 954 (VMD-954). This squadron was based in Greenville, North Carolina, and the album contains photographs of the Greenville base and of Pacific Theatre battle sites.

1) "Stand and Fight: The Story of a Destroyer in Battle," (undated); 2) USS Sterrett DD 407 19th Reunion May 1999 San Diego.

This collection contains genealogy material concerning the Tucker family of Pitt County, North Carolina, and correspondence (1983-1999), legal documents, maps and photographs related to the Tucker Family Cemetery in Greenville, Pitt County, North Carolina. Documented are attempts to keep up the cemetery, protect it from encroachment from neighboring Arlington Boulevard due to needs to widen the road, and from encroachment by neighbors.

The Watson and Boomer families of Beaufort and Hyde Counties, North Carolina, were connected through marriage. Included are original deeds from the early and mid-1800s; birth, death, and marriage dates and genealogy notes; baby book-type notes about the lives of 2 children (1885-1888) of William I. Watson (his mother was a Boomer) and wife "Ms. Charlie" Sidney Archbell Watson; World War I letters (1917-1918) written by William E. Watson to relatives in Aurora (Beaufort County), North Carolina, from Camp Sevier and Fort Jackson in South Carolina; and photographs (late 1800s-early 1900s).

Collection (1900 - 1983, undated [Bulk: 1936 - 1940]) of correspondence, newspaper clippings, photographic prints, printed forms, ephemera, printed materials, oversized materials, etc. relating to the life and career of William J. Croom (1901-1940) as a patrolman in Kinston, North Carolina, a member of the first North Carolina State Highway Patrol in Greensboro, N.C., and Director of Public Safety in Durham, N.C.; Also included are Croom and Peed family genealogical files and photographs.

Papers of Andrew Nelson Lytle (1934–1992, undated) documenting the life and literary career of the noted Murfreesboro, Tennessee-born, American biographer, novelist, dramatist, literary critic, educator, and editor, who became a leader and spokesman for the Southern Agrarian literary movement, including correspondence, manuscript materials, typescripts and holographs, printed materials, and loose manuscript items transferred from the Stuart Wright Book Collection.

Collection includes papers related to the personal life and non-university activities of East Carolina University History Professor Lawrence Fay Brewster (ECU professor from 1945 to 1969) for whom the Lawrence F. Brewster Classroom Building on campus was named in 1974. Included are materials (1857-1945) related to his parents and ancestors, Brewster's early life and education through earning his Ph.D., his teaching job at Cranleigh School for Boys in St. Petersburg, Florida, and his work with the Works Progress Administration as Research Editor for the Historical Records Survey of North Carolina. The vast majority (1960-1991) of the collection concerns his work as historiographer for the Episcopal Diocese of East Carolina and writing his "History of the Protestant Episcopal, The Diocese of East Carolina."

Papers of John Updike (1946-2010, undated) documenting the life and literary career of the noted Reading, Pennsylvania-born American novelist, poet, short story writer, art and literary critic, cartoonist, golfer and golf writer; including manuscripts and manuscript volumes, correspondence, clippings, photographic materials; also including drafts & proofs of published materials, including interviews for Writers at Work: Seventh Paris Review; original art; loose manuscript items transferred from the Stuart Wright Book Collection; also oversized materials.

Papers (1903-1951) including correspondence, photographs, negatives, pamphlets, letters form of radio shows, reading, social events and miscellaneous.

Papers (1789-1906) including correspondence, financial papers, legal records, public school registers, newspapers, promissory notes, receipts, copy of marriage and birth, etc.

The Edward Baxter Billingsley Collection (1817-1819, 1938–1999, undated) consists of historical research materials, drafts, and a typescript copy (643 pages) of One Destroyer and World War II: A History of the U. S. S. Emmons (DD457-DM22), by Edward Baxter Billingsley, that he later published as The Emmons Saga: A History of the U. S. S. Emmons (DD457 – DM22). Also included are photographic prints, photocopied naval documents, and microfilm reels concerning his research, and correspondence (1817-1819) related to his dissertation on Chilean and Peruvian wars of Independence.

This collection includes 108 Chatham County, North Carolina, warrants (1804-1840); 2 Onslow County, North Carolina, grants (1788, no date); and 1897 financial receipt with 4 handwritten medicinal cures by Wyley M. Cates of Teer and Alamance County, NC, and print ads for his cures.

This collection contains over 100 letters (1885, 1892-1897) written to Sallie Dromgoole Cotten (1876-1972), daughter of Sallie Swepson Southall Cotten and Robert Randolph Cotten, either while she was at home at Cottendale in Falkland, Pitt County, North Carolina, or at Notre Dame of Maryland Preparatory School and Collegiate Institute in Baltimore. The letters are written mainly by Sallie's female friends, but also some male friends in the 1890s (1892-1897) The correspondents are family, associates, and friends, especially schoolmates. Topics are mainly related to interests of college women and men. Also included are ephemera such as dance cards and dance invitations especially to "German" dances which were large popular events among wealthy white families in Eastern North Carolina tobacco towns in the 1890s.