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Collection (1848-2002) of Pace family papers, including documents; photograph and postcard albums; scrapbooks; loose photographs, deeds, legal documents, and newspaper clippings; printed yearbooks, catalogs, textbooks, and newspapers; genealogical charts, postcards, brochures, World War I Army Medical Corps documents, and ephemera relating to physician Dr. Karl Busbee Pace, Sr. and his sons, Dr. Karl B. Pace, Jr., Charles Taylor Pace, and J. T. W."Tommy" Pace and their families in Robeson, Chatham and Pitt counties, NC.

Collection (ca. 1936-1997) relates to the life and career of Arthur Greenville McIntyre; an Lieutenant Commander of the United States Navy who was a U.S. Naval Academy graduate (Class of 1941) and who served in the Pacific theater of World War II. McIntyre served on the submarine U.S.S. Grenadier until it was lost in April 1943 by Japanese bombing. As a result of the attack, he became a prisoner of war of the Japanese and was not released until September of 1945. The bulk of the collection is on McIntyre's naval career but there is also material containing his biographical information and information on his time as a prisoner of war. Of particular interest are documents that have information on the Japanese who ran the POW camps and who were tried in the war crimes trials that were held in Japan. The documents lists their names and the sentences they received as a result of those trials. The majority of the documents in the collection are in English but some are in Japanese and Spanish with no translation.

Papers of physician C.H. Brantley (1860 – 1942). The papers consist mainly of a medical school photograph with cadaver and prescription slips.

This collection consists of photographs, slides, and negatives of images used in Greenville—Pitt County Chamber of Commerce, Inc. (North Carolina) publications in the 1970s through 1990s. Also included are some audiotapes.

Collection (1950 - 2011), including correspondence, photographic prints, ephemera, subject files and published materials, relating to Democratic Party politics in North Carolina and Washington, DC, especially Leggett's activities as chief of staff for Robert B. Morgan, who was Attorney General of North Carolina and U. S. Senator, 1970-1980.

This collection (2001-2008) has printed material, minutes, correspondence, ephemera and other documents donated by Dr. Keats Sparrow who participated as a member of the North Carolina First Flight Commission and its Education Committee during the 100th Anniversary celebration of the First Flight. The collection also contains a 2003 commemorative booklet "First Flight Visions celebrating the 100th Anniversary of Powered Flight," information from the International Commission's 2001 Flight Symposium about the Wright Brothers, photographs, clippings, and brochures. Other items are a travel mug, automobile license plate, pins, shoulder patches and commemorative items.

Papers (1893-1973) including of correspondence, notebooks, pamphlets, books, photographs, newsletters, family letters, photographs, slides, maps.

Papers (1885-2009) of prominent Washington, NC, attorney Junius Daniel Grimes, who was member of the firm Ward and Grimes, and his family and business associates, including correspondence, legal records, land records, financial papers, publications, taxes, installments, bills, survey, map, etc.

Papers (1821-2000) consisting of correspondence, receipts, promissory notes, summons, chattel mortgages, pictures, Bible records, advertisements, etc., related to the Elmore family of Wayne and Lenoir Counties, North Carolina, and related families.

Papers and artifacts, primarily notebooks, account books, journals, instruments, and devices of three generations of Alfred F. Hammond's, all physicians in eastern North Carolina.

Papers (1928-1979) including correspondence, memorandums, classified and unclassified documents, military records, reports, poems, photographs, yearbooks, news articles, maps, regulations, and miscellaneous.

The collection includes publications created by the ECU School of Medicine and the University Health Systems of Eastern Carolina, formerly Pitt County Memorial Hospital.

Papers (1917-1969) include first World War diaries, correspondence, advertisements, pamphlets, brochures, periodicals, clippings, magazines, books, etc.

Correspondence, contracts, ship plan drawings, manuals, photographs, brochures, and other files pertaining to the construction, repair, and marketing of vessels, both military and civilian.

Papers (1891-1918) including correspondence, legal materials, financial records, ledgers, estate papers, real estate records, political material, letters and miscellaneous concerning Jesse W. Grainger of Kinston, North Carolina, a very successful truck farmer, owner of the first tobacco warehouse in Kinston, and very active in civic affairs.