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The collection includes publications created by the ECU School of Medicine and the University Health Systems of Eastern Carolina, formerly Pitt County Memorial Hospital.

Papers of Richard Herman McLawhorn, Jr. (1923-1987) of Ayden Township, Pitt County, North Carolina that are related to his childhood and his service during World War II as a bombardier on the bomber "Tail Heavy" with the U.S. Army Air Corps 485th Bomb Group.

The Nell Wise Wechter Papers contains copies of the author's books, Taffy of Torpedo Junction (1957), Betsy Dowdy's Ride (1960), Swamp Girl (1971), and The Mighty Midgetts of Chicamacomico (1974). Also included are the typed and written drafts, typed manuscripts with revisions, original manuscripts, and galley proofs for her books. There is also correspondence from the Library of Congress, British Embassy, and Mariners Museum regarding Wechter's requests for information to assist her in writing her novels.

The Nathaniel Pettit Joy Collection (1913-1919 [Bulk: 1918-1919], undated) consists primarily of letters he and his wife Mary received from two New Jersey soldiers and two New Jersey sailors written to Nathaniel Pettit Joy and his wife Mary of Groveville, New Jersey. The soldiers, Raymond "Bud" Danley and William "Bill" Inman were privates in the Headquarters Company of the 309th Infantry Infantry, 78th Division of the American Expeditionary Force; they wrote from England, France and Fort Dix (New Jersey); the sailors were A. C. Griffiths sailor aboard the battleship USS ARIZONA in 1918-1919; and Cousin Edwin, who served aboard the USS SIBONEY, a hospital ship, 1918-1919; the collection also includes several miscellaneous items, including French postcards, photographs of unidentified soldiers and sailors, and a letter written from a Cpl. Walter P. Rogers, who was a guard at a Russian prisoner of war camp in Chemnitz, Germany early in 1919.

Papers (1937–1950) of U.S. Navy officer, U.S. Naval Academy class of 1941, including correspondence and grade reports of USNA; rosters, photographs, and bulletins from the USS New Mexico (BB-35); newsletters, photographs, and clippings from the USS Quincy (CA-71); Carrier Division 5 (CTF-77) and miscellany.

Papers (1736-1979) of the Whitehurst family of Craven County, North Carolina, including correspondence, genealogical information, land records, financial records, church related items, pamphlets, brochures, greeting cards, invitations, UDC records, clippings, photographs, and miscellaneous.

Collection (1942-1988) including correspondence, oral reminiscences, logbooks, technical data, veteran's information, and newsletters, newspaper clippings.

Papers of physician Verne S. Caviness consisting of a typescript, carbon copies of typescripts, illustrations for journal articles, and a typed letter; all related to Dr. Caviness' publication of two journal articles.

Includes Carolyn Grace Warren's diploma in nursing from Park View Hospital Training School for Nurses, a nursing school handbook, photographs of Warren's graduating class, books, prints, and case studies conducting by Warren during her training.

Collection (ca. 1941—1959) of correspondence, manuscripts, printed forms, and printed works relating to the Sanderson family of Kinston, North Carolina, and the military service of Cpl. Claude Sanderson Jr. in Co. H, 129th Infantry Regiment, 37th Infantry Division, and Pfc. James Earl Sanderson in Battery A, 449th Field Artillery Observation Battalion and Co. B, 1st Brigade, 119th Infantry Regiment, 30th Infantry Division.

Collection (1904-1909) of grade reports, tuition bills, and academic progress letters relating to the education of Mattie Archbell Anderson at Dortch Academy, Rocky Mount, NC; Littleton Female College, Littleton, NC; Louisburg College, Louisburg, NC; and Louisburg Female College, Louisburg, NC. Also included are items (2008-2010, undated) related to Mrs. Anderson's daughter Mattie Archbell Anderson Bishop of Enfield, NC.

Eighteen photographs of Gladys Howard and her friends at East Carolina Teacher's College in the late 1920s.

Records (1903-1954, undated) of the Leggett (NC) general store.

Collection (ca. 1802-1951) of material compiled by members of Christ Episcopal Church of Elizabeth City, North Carolina, related to the church's history including photographs, blueprints, correspondence, scrapbooks, church history booklets, annual reports, parish yearbooks, programs, clippings, and budget documents.

Lecture notes, business accounts, newspaper articles, military papers, and artifacts of the Garrenton Family. The Garrentons include: James Francis Garrenton (1839-1913), Cecil (1883-1935), and Connell (1910-1985). They established the Bethel Clinic near Greenville, North Carolina.