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Diary written by Edward L. Williams, while serving in the United States Marine Corps, describing his voyage, aboard the USS Alaska, to the European Station under the command of Captain Samuel "Powhatan" and under the direct supervision of Captain W. R. Brown, including their cruise along the Italian coast , frequent port calls, shipboard life, behavior of sailors, and his friendships and acquaintances among the ship's crew.

Advertisements for medicine, likely from between 1870 and 1910. The advertisements include patent medicine trade cards, blotter paper advertisements, broadside advertising sheets, booklets, and calendars. "Patent medicines" were often promoted as "cure-alls" for many parts of the body and their ingredient list (if any) was often inaccurate.

Papers (1927-1960) consisting of correspondence, clippings, articles, and speeches on tobacco and the tobacco program.

Records (1939-2013) of national and divisional offices of the U.S. Coast Guard auxiliary, including Flotilla 1301 records (1942-1945), consisting of correspondence, muster rolls, directives, minutes, services records, speeches, duty records, photographs, copies of the Navigator and other publications, conference records, regulations, policy statements, training materials, histories, films, oral histories, and scrap books. 718 boxes. 471 c.f. (c.f. rev. 8/21/2003)

This collection contains materials related to the Iota Upsilon Chapter of Lambda Chi Alpha at East Carolina College.

This collection contains a photocopy of a letter written by Thomas J. Jarvis of Greenville, North Carolina, on February 1, 1890, to Horace P. Gates in New York, New York, accepting Gates' invitation to meet with Civil War veterans of the Roanoke Island Campaign and describes his own service during the Civil War. Also included are many items related to Eastern North Carolina citizens relative to life during World War II such as ration books, application for appointment as an Aviation Cadet, farm allotments, and photographs of Basic Training Camp #10 in Greensboro. Unrelated items include photographs of Sycamore Hill Baptist Church in Greenville, North Carolina, on February 11, 1969, after it had burned presumably due to arson.

This collection contains materials related to the administration of Bill Shelton.

This collection contains the records of Interim Chancellor Dan Gerlach.

This collection contains materials related to William Muse's administration.

Papers (1830 – 2010, undated) [Bulk: 1940-1970] documenting the life of Robert Lee Humber, Jr., who was born 30 May 1898 – and died 10 November 1970, in Greenville, North Carolina; after attending local schools he earned a BA from Wake Forest College, 1921; he then attended Oxford University in the United Kingdom as a Rhodes Scholar, 1921-1923; he then earned a MA from Harvard University in 1936; he moved to Paris, France, in 1926, where he married and served as an American Field Service fellow, 1926-1928, and subsequently earned a fortune as an international lawyer, art dealer, and businessman, 1930-1940, until the Fall of France, in 1940, when he, his wife, and their two sons, John and Marcel, fled the German invasion - his infant daughter Eileen died during their escape - and he returned to North Carolina, where he purchased a farm on Davis Island, established a legal career, and devoted himself to public service and to a wide range of philanthropic causes, as an educator, civic, cultural, political and religious leader; beginning in 1940, he became well-known nationally and internationally for establishing and leading the World Federation movement as a way to promote lasting world peace through international law; statewide for persuading the General Assembly and the Kress Foundation of New York to fund and establish the North Carolina Museum which opened in 1956; also as an art collector and patron of local and regional volunteer organizations; as a Democratic state senator from Pitt County, 1958-1964; as an educator who led the effort to create Pitt Technical Institute (later Pitt Community College); as a leader in the Southern Baptist denomination becoming a member of the Board of Trustees of Wake Forest College and other Baptist institutions; and as an attorney and business leader and developer; additionally, the collection includes historical files documenting the history of the World Federation in the United States, compiled by his son, John Leslie Humber.

Collection (2001–2002) of materials concerning the American destroyer USS Emmons (DD-457/DMS-22), which was the last American naval fighting ship to be commissioned prior to U.S. entry in World War II, and which sank on 5 April 1945, after being badly damaged by Japanese kamikaze attacks to the north of Okinawa. Compiled by a veterans' association, the collection includes a membership roster, historical clippings, photocopies of the association's newsletters, videotape cassettes, including 1 documenting the rediscovery of the ship's resting place, on 19 February 2001, and 2 videotapes by Japanese television network, NNN, broadcast on 1 July 2001.

Papers (2006-2024) from the Tar River University Neighborhood Association (TRUNA) of Greenville, North Carolina. TRUNA was created in 1998 as a merger of two pre-existing neighborhood associations: The University Neighborhood Association (TUNA) and the Tar River Neighborhood Association (TRNA). Included are files of the president, minutes, correspondence, and files related to an initiative to save the neighborhood from planned ECU development by creating the East College Park Homeowners Association (later deemed unnecessary when ECU withdrew their plans related to expansion there). Some records of TUNA and TRNA activities are also included.

Printed materials (1960-1990) received by Drs. Joseph and Lala Steelman related to the National Democratic Party and related organizations concerning social, environmental, and political issues (1969-1990). The collection also includes family files on Steelman and Edmisten families, plus large collection of familial correspondence. Records pertaining to the Steelmans' time at East Carolina are located in University Archives.

Papers (1865-1954, undated) consisting of correspondence, speeches, financial and legal records, a minute book, a guest register, photographs, newspapers, genealogical notes, deeds, etc., related to the career of Dr. Charles O'Hagan Laughinghouse (1871-1930) of Greenville, N.C., and to the Laughinghouse and related Stokes families. Besides having a successful practice in Greenville, Dr. Laughinghouse was a respected member of the North Carolina State Board of Health for several years beginning in 1911, served as president of the Medical Society of the State of North Carolina in 1916 and 1917, and served as State Health Officer from 1926 until his death in 1930.