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The papers track the history and development of Pitt County Memorial Hospital(previously Vidant, now ECU Health) and Brody School of Medicine, including scrapbooks, photographs, publications, and videos.

Papers (1819-1872) of Thomas Sparrow (1819-1884), a Washington, N.C., lawyer until the outbreak of the Civil War. He was commissioned a captain in the Confederate Army in 1861 and served at Fort Hatteras until he was taken prisoner by Union forces in August of that year. After the war he returned to Washington and represented Beaufort County in the North Carolina General Assembly in 1870 and 1881. Papers include correspondence, military papers, prisoner of war diary kept at Fort Warren, Massachusetts, articles, essays, speeches, accounts, clippings, genealogical notes, and Sparrow family Bible records. Also included are letters (1858-1881) written by Thomas Sparrow's son George Attmore Sparrow (1845-1922) to him describing life in Okaw/Arcola, Illinois, at Hillsborough Military Academy, in military service as a Confederate soldier, and in his post-war life as a farmer and lawyer and later as a Presbyterian minister.

This collection (1791-1960) documents the horse and mule business, farm operations, land transactions, saw mill operation, and other business enterprises of Edward Cyrus Winslow (b. 1886) of Tarboro, Edgecombe County, N.C. Included in the collection are correspondence, financial and legal records such as account books, ledgers, bills and receipts, contracts with other mule dealers, promissory notes, agricultural liens and chattel mortgages, deeds, and lease and rental agreements. Also included are superior court records, blueprints of farm tracts and dairy equipment, printed material, business and family photographs, and a small quantity of family correspondence.

Collection (1950 - 2011), including correspondence, photographic prints, ephemera, subject files and published materials, relating to Democratic Party politics in North Carolina and Washington, DC, especially Leggett's activities as chief of staff for Robert B. Morgan, who was Attorney General of North Carolina and U. S. Senator, 1970-1980.

Lemuel Showell Blades, III, (1933-2011) began his career as a lawyer and then went on to become the president of the Norfolk Telephone Company while serving on a number of committees in Elizabeth City, and New Bern, North Carolina. This collection spans from 1711-2011 and includes newspaper clippings, photographs, genealogical charts, letters, oral histories, books, videos, and career files. The strength of this collection is the genealogical overview of the several generations linking to the Blades family.

Diploma for Charles B. Walton from the Baltimore College of Physicians and Surgeons.

Papers (1916-1962) including correspondence, contracts, financial records, certificates, legal papers, income tax forms, Masonic records, biographical sketch.

This collection contains Mary Stephenson Hammel's items from her time as a student at East Carolina which are her diploma, publication award for her work on the yearbook, and letter patch for her participation in the Women's Athletic Association. Additionally, there is a 2005 photograph of Mary and a copy of the Alumni Association's booklet made for the class of 1955's Golden Alumni event.

Papers (1891-1896) consisting of correspondence from friends and relatives, correspondence of social reflection, cultural mores, climatic conditions in Virginia.

Papers (1907) including doctor's notes, medical orders, nurse's notes.

Papers (1866) including correspondence, diary, conversion of people, etc.

Records (1973-2015) of the North American Society for Oceanic History (NASOH) including correspondence, membership lists, annual conference materials, book awards, bibliographies, newsletters, treasurer's records, programs, and publications.

Papers (1920-1953) including correspondence, membership lists, financial records, meetings, essay, newspapers, magazines, clippings, scrapbook, reports, Lee Jackson Day celebration, etc.

Letterbook (1861-1864) consisting of handwritten transcripts of letters.

This collection features oral history interviews conducted in 2011 with twelve members of the Latino community of eastern North Carolina who occupy positions ranging from recognized leadership to informal influence in the lives of Latino youth. Their occupational backgrounds are varied including professional, entrepreneurial, technical and working class trades. The interviewers were Dr. Ricardo Contreras and Dr. David Griffith of the Anthropology Department at East Carolina University in Greenville, North Carolina.