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Papers (1858-1957) of Rev. John C. Wooten including correspondence, clippings, photographs, postcards, printed materials, and ephemera dealing with the American Civil War, telegraph operations, missionary experiences in Japan, Korea, and China, twentieth-century family life, and other topics.

Collection (1719-1910) including newspaper, periodicals, sheet music, poems, photocopies of legal records, letters, agriculture, Livestock Journal, magazine etc.

This collection contains genealogy material concerning the Tucker family of Pitt County, North Carolina, and correspondence (1983-1999), legal documents, maps and photographs related to the Tucker Family Cemetery in Greenville, Pitt County, North Carolina. Documented are attempts to keep up the cemetery, protect it from encroachment from neighboring Arlington Boulevard due to needs to widen the road, and from encroachment by neighbors.

Original material collected by Horace H. Mewborn, Jr. including printed maps, letters, diaries, clippings, cartes de visite, tintypes, an ambrotype, memoir, ledgers, reports, and drawings related to the Civil War especially pertaining to Col. John S. Mosby and his 43rd Virginia Cavalry Battalion, Col. Elijah V. White and his 35th Virginia Cavalry Battalion, North Carolina Cavalry Units, and the battles fought in the New Bern, NC, vicinity. Also included is his voluminous research related to the above listed units and the Army of Northern Virginia and the Army of the South.

This collection contains the records (1872-2014, undated) for the Cumberland Lodge No. 5, Knights of Pythias, in Fayetteville, North Carolina. Types of material included are correspondence, financial records, rosters, visitors' registers, by-laws, deeds, records of proceedings and printed material. Membership information often gives a member's age, dates when each class or rank was attained, date of death and what dues were collected. In some cases indication is also given as to when membership was withdrawn, suspended or reinstated.

Papers, certificates, photos, and artifacts of Dr. Edwin Wall Monroe. This collection contains a great deal of information regarding the development of the East Carolina School of Medicine, including planning, politics, legislation, advertisement, construction, partnerships, details of the personnel involved, groundbreakings and other ceremonies, departments, additional buildings, and community services.

Papers (1942–1948) including naval campaign file for Solomon Island, photographs, citations, pamphlets, battle, pictures.

Letterbooks (1864-1866, 1868) including correspondence, letterbooks of handwritten copies of letters, one speech, one cash book, one invoice book, one monthly statement book, one order book, two poems.

Correspondence (1942-1945) between Mary A. McLeod, through her work in South Carolina with the USO, and several members of the U.S. Armed Forces during World War II; and correspondence (1936-1949, undated) between Lt. John D. Grier and his family in the Charlotte, North Carolina, area during his military service before and during World War II. Other correspondence in the collection is between Grier and his brother who was a prisoner of war in Germany during World War II. The collection spans 1936-1949 and includes correspondence, photographs, and a Blue Star Service Banner which would have been displayed in the front window of a home where a family member was serving in the U.S. MaryArmed Services during World War II. Mary A. McLeod and John D. Grier were married in 1948.

Muster roll for a detachment of the 29th Regiment U. S. Colored Troops Detachment under the command of Capt. Wilson Camp, dated June 30 – August 31, 1865. The roll documents the names, ranks, enlistment data, and service records of the 17-man detachment consisting of soldiers from Illinois, Indiana, and Maryland.

This collection (1980s-2010s) contains material related to the life of Michael J. Hamer, an English professor at East Carolina University in Greenville, North Carolina, from 1986 through 2013, and a prolific songwriter, singer, and band leader who died in 2017. Included are notebooks containing his handwritten lyrics, poems, photographs, reel to reel tapes, clippings, and other material pertaining to his musical career.

Papers (1941-1945) of U. S. Naval officer, graduate of the U. S. Naval Academy (1941), including his Reminiscences of World War II.

The collection includes publications created by the ECU School of Medicine and the University Health Systems of Eastern Carolina, formerly Pitt County Memorial Hospital.

Papers (1966-1992, undated) of Carol Leigh Humphries, a Southern Baptist Conference missionary woman from Person County, North Carolina, including letters to family and friends in North Carolina documenting her career as a missionary in Jos, Kaduma and other locations in Nigeria, British West Africa; newspaper clippings related to Humphries' missionary work; also genealogical notes of Mrs. Emma H. Blalock.

Lenoir County Colonial Commission Records (2006–2007, undated) pertaining to events and activities honoring and celebrating the life and accomplishments of landowner, Revolutionary War general, and six term governor of North Carolina, Richard Caswell, held in Kinston, N.C., 12–19 August 2007; also including newspaper clippings, programs of events, correspondence, financial records, printed materials, digital materials, drafts, and documents regarding the publication of Clayton Brown Alexander's 1930 PhD dissertation, which was a biography of Richard Caswell, entitled "First Patriots and the Best of Men: Richard Caswell in Public Life," which was edited by W. Keats Sparrow.