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The collection consists primarily of photographic, blueprint, journals, class photos, and other advertising materials used and/or created by the Medical News & Information department of East Carolina University.

This collection contains copies of the ECU Medical Review and later iterations of the publication.

Papers (1720-1872, 1936) including correspondence, legal documents, estate records, accounts, promissory notes, shipping records, receipts, an apprenticeship bond, tombstone records, tax lists.

This collection contains copies of The Hook: ECU's student interest magazine.

The papers and audiovisual materials of Dr. Karen Baldwin, a professor of English and Folklore at ECU.

This collection contains a printed publication by Carolina Connection concerning Directions for the ECU Community.

Collection contains a newspaper clipping (6/10/1923) entitled "Christian Church Growth in 20 Years Proud Record, Dedication Services Sunday" from the Greenville, North Carolina, Daily Reflector.

A letter written February 17, 1841, by missionary Rebecca Townsend Jamieson, a wife and mother, who was living with her husband and children in Subothro (now Sabathu) in the Himalaya Mountains in Northern India.

This collection contains copies of Purple Report, which was the monthly newsletter of the ECU Educational Foundation.

This collection contains issues of The Pirates' Chest, which is the official publication of the ECU Pirate Club.

Papers of ECU professor and writer Vernon A. Ward, Jr. containing his published works, literary manuscripts, poetry drafts, correspondence, clippings, memorabilla, and photos.

Papers (1938–1993 [Bulk: 1938–1953]), of U.S. Naval Reserve officer and destroyer escort commander, including official files and service records, and a History of USS SC-631; postwar correspondence relating to the Destroyer Escort Commanders Organization (DECO); a History of the USS Kendall C. Campbell (DE-443), by Cdr. Richard E. Warner; a scrapbook, compiled by Cdr. Warner's father, entitled Sub Chaser Navy: World War II, which documented the achievements of destroyer escorts, and Warner's service in destroyer escorts, patrol craft, and sub-chasers; also oversize material including a blueprint of USS PC-497 [renamed SC-497]; and a laminated fact sheet entitled United States Ship USS Kendall C. Campbell (DE-443) including orders, letters, printed forms, certificates, commissions, and documents signed by Admiral Chester Nimitz; Secretaries of the Navy Frank Knox, Francis P. Matthews, Claude A. Swanson, and James Forrestal; by Governor of California Frank F. Merriam.

William "Bill" Cain papers contain materials from his career at ECU and personal items.

The collection includes publications created by the ECU School of Medicine and the University Health Systems of Eastern Carolina, formerly Pitt County Memorial Hospital.

Collection contains issues of the Opportunity newsletter published by the Equal Opportunity Programs Office.