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Letters and ephemera (1926-1929) related to the life of Agnes Wadlington [Barrett], who was born in Trigg County, Kentucky in 1902, before she took a job at East Carolina Teachers College (now East Carolina University) as secretary to the president of the college. Also found with these papers are many photographs of members of the Putnam family of Murray, Kentucky. The only connection between Mrs. Barrett and the Putnam family appears to be that both she and Louise Vey Putnam Carter's husband Herbert Leland Carter both worked at East Carolina University. An 1982 engagement calendar kept by Mrs. Barrett documents her life during retirement in Greenville, North Carolina.

The Jack Minges Papers include photographs, clippings, and memorabilia related to the Minges family's relationship with East Carolina, especially the dedication of Minges Coliseum.

Copy of The Greatest Anti-Submarine Action of All wars (an account of the World War II action of the USS George (DE-697) and copies of supporting documents, including the USS George war diary for May 1944.

The Alice Morgan Person collection (1874-1943, 2004-2008) contains ledgers, testimonials, advertisements, correspondence, and news clippings related to the Mrs. Joe Person Remedy Company. The Remedy was developed by Alice M. Person (Mrs. Joe Person) of Franklinton, Charlotte, and Kittrell, North Carolina, and marketed by her and later her son Rufus M. Person. Other material pertains to the sale of her arrangements of popular songs, and to family life.

Collection (1821-2000, undated [bulk: 1989-2000]) of correspondence, family histories, genealogical charts, copies of deeds, cemetery records, Bible records, miscellany and oversized materials relating to Christopher DeGraffenried, also known as Baron Christoph von Graffenried, who established a colony of Swiss and Palatine emigrants at New Bern, North Carolina, in 1710; and also relating to his ancestors and descendants and the DeGraffenried Association, of Gulfport, Mississippi and San Antonio, Texas, which was established to preserve the family history and to maintain contact between family members; in English, German, Italian, and French language.

Papers 1937-1997 (Bulk 1974-1997) pertaining to Lee A. Wallace Jr.'s military service during World War II, including a scrapbook documenting Wallace's service in Battery "C", 2nd Battalion, 113th Field Artillery Regiment (formerly designated 117th Field Artillery); also referred to as 113th Field Artillery Battalion, 30th Infantry Division, North Carolina National Guard, based in Washington, N.C., including newspaper clippings, orders, photograph prints, and rosters; correspondence and newsletters pertaining to 30th Infantry Division reunions; a copy of the American Battle Monuments Commission's pamphlet entitled "30th Division: Summary of Operations in the World War" (1944); also oversized maps of the 30th Division's offensive operations during World War I, 1917-1918, removed from the pamphlet; in English, Dutch, & French language.

Papers (1854-1857) including Day book for Nash County school teacher, notes, listing of student names, rules of school, dates of terms etc.

Papers (1910-1956, undated) of U. S. naval officer, graduate of the U. S. Naval Academy, 1912, who was executive officer aboard the USS FANNING when it sank a German U-Boat U-58 during World War I, and during World War II commanded the battleship USS NORTH CAROLINA in the South Pacific, consisting of correspondence, battle reports, reports, speeches, Naval War College papers, citations, publications, newspaper clippings, photographs and miscellaneous.

Genealogical material on Tyson Family of Pitt County, North Carolina, prepared in 1982 by Dr. Bruce C. Tyson, Jr.

Private journals/ships' logs (October 1860 - July 1878) of Benjamin Thompson, master of the brigs Progressive Age and T. A. Darrell, and the ships Sportsman, and Harrisburg (v. 1, 1860-1865), commander of the ship Columbia (v. 2, 1865-1870), master of the ship Peruvian (v. 3, 1870-1872), and captain of the clipper ship Great Admiral (v. 4, 1874-1878), illustrating his career aboard sailing ships trading between England, the east and west coasts of America, Southeast Asia (Singapore, Manila, and Hong Kong), and Tokyo, Japan, including highly detailed and dramatic accounts of shipboard life and commercial operations.

Papers (1775 [1932-1966] - 1980, undated) consisting of correspondence, speeches, a diary, essay, reports, photographs, an autobiography, scrapbooks, newspaper clippings, maps, pamphlets, financial records and miscellany.

Journal of a Cruize in the USS Independence, Commodore William Bainbridge's Flag Ship, Capt. William M. Crane, Commander, from Boston, July 2nd, 1815 (3 July–15 November 1815), compiled by an anonymous crew member, which describes the first overseas mission of the first ship of the line commissioned by the United States Navy, to deal with the piratical acts of the Barbary Powers against American merchant commerce in the Mediterranean Sea, bound in original calf leather over marbled boards, entries clean and legible; also a letter from William M. Crane, Commanding Officer, USS Delaware, Port Mahon (20 September 1829) to Lt. William N, McKean, U.S. sloop Warren, ordering him to report to Lt. Thomas M. Newell, commander of the U.S. schooner Porpoise.

Minutes, programs, correspondence, journals, reprints, reports, posters, and miscellaneous records (1902-2016) documenting the North Carolina Academy of Science.

Papers (1892-1940, 1960-1964, 1972, 1988) consisting of correspondence, pamphlets, photographs, clippings, newspapers and a book pertaining to the life of Rev. David Wells Herring, a Baptist missionary in China. The book titled Papa Wore No Halo was written about Herring by his daughter Susan Herring Jefferies Taynton.