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Collection holds medical notebooks from various sources. Two notebooks found in the Laupus Library History Collection with no presently known provenance. One notebook is a dietetics notebook from E. Alexander at General Hospital, Patterson, New Jersey. The other notebook is Dr. Edward Beach Crowell's medical recipe book. An additional notebook was added to the collection in 2018. This notebook, purchased from Palinurus, was the business record for a Connecticut physician in the 1840s. Two more notebooks were added in 2022. They document medical products.

Letters and ephemera (1926-1929) related to the life of Agnes Wadlington [Barrett], who was born in Trigg County, Kentucky in 1902, before she took a job at East Carolina Teachers College (now East Carolina University) as secretary to the president of the college. Also found with these papers are many photographs of members of the Putnam family of Murray, Kentucky. The only connection between Mrs. Barrett and the Putnam family appears to be that both she and Louise Vey Putnam Carter's husband Herbert Leland Carter both worked at East Carolina University. An 1982 engagement calendar kept by Mrs. Barrett documents her life during retirement in Greenville, North Carolina.

Papers (1845-1937) of Pasquotank County, N.C. farming and mercantile family, including correspondence, legal papers, financial records, account books, ledgers, a map, cost of advertisements, business cards, etc. Also glass negatives of Hollowell family members, house exterior, room interiors, logging scenes, beach scenes, Nags Head hotel, and an 1899 classroom cadaver dissection scene.

Records (1955, 1960-2016) of the Pitt County Historical Society (of North Carolina), including minutes, bylaws, correspondence, and clippings, photographs, financial records, programs and photographs. Also included are the records (1949-1950) of the Greenville Music Club, the Red Banks Home Demonstration Club (1946-1950), old Greenville advertising fans, and a scrapbook for the Town and Country Senior Citizens Club (1978-1999).

As I Saw It: From Pearl Harbor to Guadalcanal, A 1993 Interview with Capt. John E. Bennett, USN (Ret.), member of the U. S. Naval Academy Class of 1941.

The Jack Minges Papers include photographs, clippings, and memorabilia related to the Minges family's relationship with East Carolina, especially the dedication of Minges Coliseum.

Papers (1760 [1880] - 1935) including correspondence, financial papers, account books, daybooks, essays, speeches, legal records, land records, notebooks, etc. of Eastern North Carolina farmer, leader of the NC Tobacco Growers Association, and NC Secretary of State (1901-1923), etc.

Printed materials (1960-1990) received by Drs. Joseph and Lala Steelman related to the National Democratic Party and related organizations concerning social, environmental, and political issues (1969-1990). The collection also includes family files on Steelman and Edmisten families, plus large collection of familial correspondence. Records pertaining to the Steelmans' time at East Carolina are located in University Archives.

Papers (1918-2005) relating to Greenville and Enfield, North Carolina boy scout leader including his World War I Diary recounting his service in the 14th Company, 4th Training Battalion, Depot Brigade and the 218th Ambulance Company in the American Expeditionary Force in France, 1918-1919, camp schedule, list of letters received and answered, addresses of French women, debts, English - French phrase, movements, places visited, and observations on daily military activities; memorials after his death; biographical sketches and clippings; letters and clippings describing him; and photographic prints of him in his World War I uniform. In English and French language.

Diary compiled (8/19/1943 - 9/15/1945) while serving as a US Navy Electrician's Mate 2/c aboard the USS Essex (CV 9) during World War II, including diagrams of electrical equipment, descriptions of daily life at sea; defending against air and torpedo attacks; attacking the Japanese-held islands of Marcus, Wake, Rabaul, Tarawa, Marshalls (Roi, Kwajalein) Truk, Saipan, Bonin, Guam, Philippines (Mindanao, Luzon, Cebu), Okinawa, Formosa, Indo-China, Tokyo, Iwo Jima, and the Japanese main islands; the naval battles of the Marianas Islands, the Philippines Sea, the Philippines typhoon of 1944, and attacks by kamikazes.

Letter (1864) from commander of the 67th Regiment N.C. Infantry requesting a father to send his sons back to the regiment.

Papers (1871-1956) including correspondence, speeches, photographs, financial records, clippings, a scrapbook, letters, and miscellaneous material.

Founding documents, logos and other designs, financial records, membership records, correspondence, newsletters, and articles concerning the Cape Lookout Yacht Club (1998-2005), Morehead City, NC.

Diaries, journals and letters (1897-1906, 1986-1988) of Mormon missionaries in Eastern North Carolina (1897-1906), including William A. Adams, 1900-1902, James Godfrey, 1899-1901, William M. Hansen, 1897-1898, William R. Hobbs, 1901-1903, Lewis Johnson, 1903-1905, William A. Petty, 1905-1906, and James Taylor, 1900-1902, along with Memoirs, Notes, clippings, anecdotes and other materials compiled by Joel Grant Handcock, for use in the book Strengthened by the Storm.