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Record (1902-1967) consisting of correspondence, tobacco records, financial and business papers, ledger, etc.

Private journals/ships' logs (October 1860 - July 1878) of Benjamin Thompson, master of the brigs Progressive Age and T. A. Darrell, and the ships Sportsman, and Harrisburg (v. 1, 1860-1865), commander of the ship Columbia (v. 2, 1865-1870), master of the ship Peruvian (v. 3, 1870-1872), and captain of the clipper ship Great Admiral (v. 4, 1874-1878), illustrating his career aboard sailing ships trading between England, the east and west coasts of America, Southeast Asia (Singapore, Manila, and Hong Kong), and Tokyo, Japan, including highly detailed and dramatic accounts of shipboard life and commercial operations.

This collection contains sixty-five letters (1846-1847) the majority of which were written by wholesale merchant Samuel Kissam of Plymouth, North Carolina, to his brother George Kissam, also a merchant, of New York City, New York, discussing mostly business matters. Also included are a couple of letters written by a ship's master at New Orleans, Louisiana, to Samuel Kissam concerning a maritime mishap.

Records (1973-2015) of the North American Society for Oceanic History (NASOH) including correspondence, membership lists, annual conference materials, book awards, bibliographies, newsletters, treasurer's records, programs, and publications.

Papers (1892-1940, 1960-1964, 1972, 1988) consisting of correspondence, pamphlets, photographs, clippings, newspapers and a book pertaining to the life of Rev. David Wells Herring, a Baptist missionary in China. The book titled Papa Wore No Halo was written about Herring by his daughter Susan Herring Jefferies Taynton.

Papers (1782-1956, undated) related to the John Gideon Taylor family of Pitt County, North Carolina, including correspondence, legal papers, estate papers, financial papers, post cards, photographs, newspapers, advertising ephemera, genealogy information, Bible records, and miscellany.

Lockey Family Collection (1891 - 2002, undated) relating to the Lockey Family, early settlers of the Pamlico River valley, including the Will of Joseph Lockey, 30 January 1746, copied from the NC Historical Commission, NC Wills, Vol. XVIII, p. 54-56 (Mss typescript); "In Memoriam of J. P. [John Peyton] Lockey (1805-1891) (Photocopy); Letter from Mrs. Donald A. Philbrick, 21 Oakhurst Road, Cape Elizabeth, ME, undated to "Dear Cousin Peyton" regarding Lockey family genealogy (Photocopy typescript); Letter from "Daddy," Tallahassee, FL, 7 September 1953, to "Dear Hope," regarding John Peyton Lockey (Photocopy typescript); and Letter from Jon Guy Diffenbaugh, Greenville, NC 3 May 2002, "To whom it may concern," transmitting the collection.

Correspondence (1910-1911, 1913-1914) between Belva Agnes Ross and her parents William Henry Ross and Lida Baynor Little Ross and her brother Wilbur "Buddy" Ross while she is attending East Carolina Teachers Training School in Greenville, North Carolina. Wilbur Ross also started attending ECTTS with his sister in October 1910, but at some point he left to attend Guilford College. The Rosses were from Edward community about three miles east of Aurora in Beaufort County, North Carolina. Belva had to withdraw from school in January 1911 because she contracted the measles, but she returned to school at least by October 1913. Also included are abstracts of the correspondence created by Belva Ross's grandson Roy A. Archbell, Jr.

Collection (ca. 1930–1954) manuscript and printed materials relating to the early history of Pitt County, North Carolina, and the Greenville High School Class of 1946, including revised manuscript drafts of a history of Pitt County, including correspondence, clippings, brochures, pamphlets, maps and rationing labels.

Papers, 1861-2011 (bulk 1940-1992), undated, of Senator Robert Burren Morgan, an ECU alumnus and lawyer, who served the state of North Carolina in a variety of elected and appointed positions. His first elected position was clerk of court in Harnett County. He was elected to the State Senate, served as president pro tempore of the Senate, and was twice elected Attorney General of North Carolina. He served in this position until 1974, when he won the United States Senate seat vacated by Senator Samuel James "Sam" Ervin, Jr. Morgan served as United States Senator from 1975 to 1981. He returned to his law practice following an unsuccessful reelection campaign and later served as Director of the State Bureau of Investigation from 1985 until 1992. Morgan served as a member of the ECU Board of Trustees for fifteen years, including nine terms as chair in the 1960s. He helped the institution achieve university status and was instrumental in establishing the ECU School of Medicine. The collection includes series relating to Morgan's family and personal matters, North Carolina Senate Files, Attorney General Files, United States Senate Files, North Carolina State Bureau of Investigation Files, and Oversized Materials Files. It includes manuscripts, photographs, audio and video materials, electronic records, printed materials, and ephemera.

Papers (1933–1987 [Bulk: 1941–1945]) of an American Red Cross volunteer who served on Guadalcanal, New Caledonia, and New Zealand, during World War II, including three drafts of her manuscript memoir of her service entitled Red Cross Adventure that was later published as No Drums, No Trumpets: Red Cross Adventure; Invitations, 1933, 1939, to Mary Ferebee Howard to attend the inauguration ceremonies for President Franklin D. Roosevelt and Vice President John N. Garner, with portraits of Roosevelt and Garner; Inauguration Ceremonies Program, 4 March 1933; Official Inaugural Concert Program, National Symphony Orchestra, Constitution Hall, Washington, 4 March 1933; Inaugural information envelope addressed to Mary Ferebee Howard; Invitations to Presidential Palace, Managua, Nicaragua, 12, 19 December 1939; also photographs, programs, memos, instruction, clippings, original art, ephemera relating to her wartime service.

Collection of papers 1941-2005, undated (bulk 1943-1946), consisting primarily of letters from Pvt. Leon W. Jackson to his sister Lois (Claude E.) Dees and to her son Tony while he was serving in the U. S. Army in Georgia and Europe; also letters from Leon W. Jackson's friend, Pfc. Jerrold S. Robinson to Lois (Mrs. Claude E.) Dees and Leon W. Jackson; also dated photograph and album.

Papers (1917-1932, 1974) of a World War I veteran who served in the 310th Ambulance Train, 78th Division, including correspondence, documents, historical reports, rosters, ephemera, memorabilia, photographs, postcards, printed forms, and printed materials.

Collection holds medical notebooks from various sources. Two notebooks found in the Laupus Library History Collection with no presently known provenance. One notebook is a dietetics notebook from E. Alexander at General Hospital, Patterson, New Jersey. The other notebook is Dr. Edward Beach Crowell's medical recipe book. An additional notebook was added to the collection in 2018. This notebook, purchased from Palinurus, was the business record for a Connecticut physician in the 1840s. Two more notebooks were added in 2022. They document medical products.

The Insurance Survey of Greenville collection contains a letter (December 31, 1937) and an insurance survey (December 27, 1937) of the city of Greenville, North Carolina.