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The papers track the history and development of Pitt County Memorial Hospital(previously Vidant, now ECU Health) and Brody School of Medicine, including scrapbooks, photographs, publications, and videos.

Sheet music of Grand March, Illustrative of "Stonewall Jackson's Way" with words by Charles Young.

Diary (1 January - 25 March 1865) of a sergeant in Company C, 110th Ohio Volunteer Infantry, 2nd Brigade, 3rd Division, 6th Corps during the Petersburg - Appomattox, VA campaign.

The Harnett County Common Schools Collection contains a few pages from a Common School Register (1879) from a school for African American students, in District No. 1, Harnett County, North Carolina.

This collection contains materials from professor emeritus Julie Fay's time at East Carolina University including materials about the Readers Writing Series, which she organized, the English Department, and materials regarding projects documenting the aftermath of Hurricane Floyd in Eastern North Carolina. It also contains materials related to her poetry and publications, as well as personal items and ephemera.

This collection contains administrative correspondence and reports, proceedings of the Chancellor's Forum and publications by the Chancellor's forum.

The collection is papers found in a doctor's bag belonging to Dr. Bennett E. Stephenson. The papers include advertisements, useful prescription information cards, handwritten notes, and notes with formularies for ringworm.

Papers (1741-1914, undated) including correspondence, legal records, land records, records of enslaved persons, financial records, receipts, ledger account book, recipes, cures, disease, etc.

Collection (1916-1918) includes 14 silver gelatin photographs and 4 printed postcards that belonged to Emil Görling, a German soldier in the 3rd Landwehr Division during World War I. The majority of the images document the 1918 German Spring Offensive in Northern France, specifically the Noyon campaign (April-August 1918). Included are images of the devastation in the area, the battlefields between the towns of Noyon and Lassigny in France, and the unit at work, at leisure and in retreat in the Lorraine area. Many of the photographs and postcards have comments written with pencil or ink in German.

The Maury York Papers are comprised of his administrive files, committee records, and records about grant projects, library director searches, and library projects including the First in the Family Cenntennial Oral History Project, the history fiction project, and the Eastern North Carolina Literary Homecoming.

This collection contains materials compiled and published by the Burroughs Wellcome Genealogy Club of Greenville, NC. The club, founded by Jean Marie Duff, was associated with the Burroughs Wellcome Fund in Triangle Park, NC. Included in the collection are family Bible records from 23 families in the eastern states.

This collection includes a copy of a typescript of the autobiographical sketch written in 1893 by Eastern North Carolina physician and educator Richard Henry Lewis, Sr. (1832-1917). It refers to important family history in his background and describes important events in his life up until 1893.

Papers (1805-1889, 1961-1963) of a wealthy, Elizabeth City, NC business family, consisting of correspondence, legal records, financial records, genealogical papers, Civil War events, letters, wedding gift, labor strikes and miscellaneous.

Account of Battle of Leyte Gulf, 1944, by Air Combat intelligence officer aboard the USS Natoma Bay. (undated)

Papers (1921-1925) including correspondence, speeches, government pamphlets, congressional records, official reports, etc. concerning service as a member of the US Congress (D-NC). C.