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Prescription orders for various pharmacies in Wilson, North Carolina between 1888 and 1891.

This collection contains postcards related to East Carolina.

This collection contains letters, clippings, photographs, and historical information about Vanceboro, North Carolina.

International pocket medical formulary used by three doctors in Spring Hope, North Carolina.

Frances Brake discusses her time as a student at East Carolina College, her family's farming in Edgecombe County, North Carolina, and her teaching career.

Items (1928-1941) related to Greenville, NC, resident James Howard Moye; and items (1955) related U.S. Coast Guard rescues in North Carolina. The Zion's Landmark Vol. 23, No. 7 and Vol. 32, No. 7 (10/15/1890 and 2/15/1899) periodical published semi-monthly by Zion's Landmark Print, Wilson, North Carolina (Primitive, or Old School Baptist) that was in the collection has since been transferred to the North Carolina Collection as of 2022.

The Louis Orr Collection contains a set of forty-eight prints of the original fifty-one print set (and one replacement print) made from etchings of North Carolina historical landmarks and architectural sites. The etchings were created from 1939 to 1952 by artist Louis Orr, a world-renown etcher, at the behest of North Carolina resident Robert Lee Humber who wanted to preserve North Carolina's heritage by providing the artwork to schools, colleges, public libraries and institutions throughout the state.

The collection includes various aspects of public health in North Carolina beginning in the early 20th century.

This collection contains histories of Webb's Chapel United Methodist Church in Lenoir County, North Carolina.

This collection contains correspondence regarding Murray's appointment to East Carolina and his teaching duties as well as materials from his involvement in the Historical Society of North Carolina.

Collection (1934-2025, undated) of programs, constitutions, bulletins, reports, membership records, memorials, correspondence, scrapbooks and clippings related to the Delta Kappa Gamma Society International and its Beta Alpha and Delta Chapters in Greenville, North Carolina, and Sigma Chapter in Kinston and Lenoir County, North Carolina.

Collection (1852-2014) includes correspondence, newspaper clippings, printed materials, and other items compiled by retired East Carolina University English professor emeritus Dr. Ralph Hardee Rives (1930-2016) relating primarily to the Hardee - Rives and related families of North Carolina and the United Kingdom, the history of Eastern North Carolina (especially Halifax County and the town of Enfield), the United Methodist Church in Eastern North Carolina, state and local and national politics, and his charitable and philanthropic interests. The earliest original documents cover the period from 1852 through the Civil War and World War I.

This collection contains 16mm game films, game day programs, team media guides, and other assorted publications related to the history of inter-collegiate football at East Carolina.

This collection includes 108 Chatham County, North Carolina, warrants (1804-1840); 2 Onslow County, North Carolina, grants (1788, no date); and 1897 financial receipt with 4 handwritten medicinal cures by Wyley M. Cates of Teer and Alamance County, NC, and print ads for his cures.

Vaughan Family Papers (1872-1900, 1969, undated) includes photograph albums containing images of family members from Hertford County, North Carolina. Also included is Uriah Vaughan correspondence (1876-1887) and a photocopy of the 1969 appraisal of Uriah Vaughan Heirs Property in Murfreesboro, North Carolina.