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Papers (1889, 1907-1958) consisting of correspondence, diaries, yearbooks, scrapbook, songbook, typescript, travel accounts, photographs, newsletters, etc., related to attendance at Salem Academy and College (1908-1911) in Winston-Salem, North Carolina, and to the work (1917 to 1950) of Protestant Episcopal music missionary Venetia Cox (of Greenville, North Carolina) in China. Also includes letters and school materials related to Lo-I (or Louis) Yin who attended Carleton College in Northfield, Minnesota, from 1949 to 1951 on a scholarship related to Venetia Cox's music missionary work with Huachung University, Wuchang, Hupeh, China.

The collection includes correspondence, printed materials, photographs, grade reports, teaching certificates and testimonials, legal documents and newspaper clippings which document the life (1891-1975) of Lenoir County, North Carolina, school teacher Julia Catherine McDaniel including her education at Hollins Institute in Virginia and her teaching career (1912-1960) in Burlington, Bethel, and Lenoir County, N.C., schools. The collection also touches on the lives of her friends, classmates, colleagues, and students and includes materials concerning the McDaniel, Harvey, Linton and related families of Kinston and Eastern North Carolina.

Papers, 1861-2011 (bulk 1940-1992), undated, of Senator Robert Burren Morgan, an ECU alumnus and lawyer, who served the state of North Carolina in a variety of elected and appointed positions. His first elected position was clerk of court in Harnett County. He was elected to the State Senate, served as president pro tempore of the Senate, and was twice elected Attorney General of North Carolina. He served in this position until 1974, when he won the United States Senate seat vacated by Senator Samuel James "Sam" Ervin, Jr. Morgan served as United States Senator from 1975 to 1981. He returned to his law practice following an unsuccessful reelection campaign and later served as Director of the State Bureau of Investigation from 1985 until 1992. Morgan served as a member of the ECU Board of Trustees for fifteen years, including nine terms as chair in the 1960s. He helped the institution achieve university status and was instrumental in establishing the ECU School of Medicine. The collection includes series relating to Morgan's family and personal matters, North Carolina Senate Files, Attorney General Files, United States Senate Files, North Carolina State Bureau of Investigation Files, and Oversized Materials Files. It includes manuscripts, photographs, audio and video materials, electronic records, printed materials, and ephemera.

This collection contains genealogical files belonging to avid genealogist Sylvia Corey (July 10, 1925–November 9, 2020) of Greenville, N.C. Included are files related mainly to the Corey (of Martin County) and Leggett (of Beaufort County) families, but also to the Gorham, Baker, Davis, Whitmell, and Wynne families among many others. Some files are related to her work with the Pitt County Family Researchers group. Also contains a zip file of born-digital genealogy material created using "Reunion" software.

The papers track the history and development of Pitt County Memorial Hospital(previously Vidant, now ECU Health) and Brody School of Medicine, including scrapbooks, photographs, publications, and videos.

Papers (1943–1945) including copies of correspondence, personal notations, orders, addresses, photographs, reminiscences, equipment lists, and reports pertaining to his World War II service with the 14th Malaria Control Unit of the U.S. Army Air Corps in New Guinea and the Philippines, 1943–1945, including references to malaria control, military issues, and incidents involving Japanese, American and Filipino forces.

Official transcript of a U.S. Navy Captain's Court-Martial proceedings (1927), photographs, letters, and poetry, along with two scrapbooks (1900-1950) maintained by Capt. Franklin D. Karns's wife, Mrs. Helen Wallace Chew Karns.

This collection includes materials related to George Sutton (b. November 1757 – d. 1827) of Durant's Neck, North Carolina, and his family. Included is a King James Version Family Bible printed in 1752, with written genealogical records of the Sutton family.

Includes medical school class notes, medical licenses, patient notes, account books, certificates, diplomas, and photographs.

Teaching materials, publications, writing, correspondence, certificates, and artifacts of Dr. Dixie Koldjeski.

This collection contains materials that date from Dowell's time as a student at East Carolina Teachers Training school and her subsequent teaching career. It contains awards received from both civic and professional organizations, clippings, personal artifacts, and scholarly works including her Masters Thesis.

Printed materials (Sept. 1999 - May 2000) including copies of Pieces of Eight, and The East Carolinian, containing articles on Hurricane Floyd and the flood that followed, football tickets, and a copy of the program for the ECU v. University of Miami football game.

Papers of James Dickey (1950-1994) documenting the life and literary career of the noted Atlanta, Georgia-born American poet, novelist and essayist, including correspondence, manuscripts, photographic prints, proofs of published works, reviews of published materials, printed material, loose manuscript items transferred from the Stuart Wright Book Collection and oversized materials, by or about James Dickey, Louis Untermeyer, and others.

Records (1973-2015) of the North American Society for Oceanic History (NASOH) including correspondence, membership lists, annual conference materials, book awards, bibliographies, newsletters, treasurer's records, programs, and publications.

Diploma for R. R. Robeson from New York Medical Institution, 1857 and from New York City University, 1858.