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A collection (ca. 1885-1918, undated) of 55 cartes de visite and cabinet cards mounted on cardboard, a scrapbook containing 11 snapshots, a manuscript, and printed materials belonging to John Miller Faison, a North Carolina physician, Democratic Party leader, and Congressman from the N.C. Third District between 1911 and 1915.

This log book contains daily entries from October 29, 1816, through November 29, 1818, for the Schooner Hilan. John Hand is the Master of the schooner which sailed between eastern seaboard ports Philadelphia, Norfolk, Richmond, and Charleston. Entries cover weather, cargo listings, upkeep of the schooner, issues with crew members and passengers, and problems with the schooner related to harsh weather.

This collection includes 108 Chatham County, North Carolina, warrants (1804-1840); 2 Onslow County, North Carolina, grants (1788, no date); and 1897 financial receipt with 4 handwritten medicinal cures by Wyley M. Cates of Teer and Alamance County, NC, and print ads for his cures.

The collection includes publications created by the ECU School of Medicine and the University Health Systems of Eastern Carolina, formerly Pitt County Memorial Hospital.

This collection contains materials and documents (1893–1990s) relating to the history of Pitt County, North Carolina Schools, highlighting especially the era of segregation. Includes Registers (1893-1920); football pamphlets (1969–1978) for J.H. Rose High School; Statement of Funds Needed Provided by Pitt County for both "Colored" and "White" schools (1916-1917); a letter (1924) from G.R. Whitfield, Supervisor for "Colored" schools; scrapbooks, scrapbook materials, and news clippings (1970s–1990s) for Third Street School, C.M. Eppes, Greenville Middle School, Agnes Fullilove School and other Pitt County schools; building specifications (1968-1973) related to Pitt County Schools; John Edwin Scoville Memorial Cups (1923-1928).

Papers (1844-1945) consisting memoir, diary, photographs, description of imprisonment, prisoner of war camp, diary, move on foot covering 603 miles, wartime log.

Collection (2001–2002) of materials concerning the American destroyer USS Emmons (DD-457/DMS-22), which was the last American naval fighting ship to be commissioned prior to U.S. entry in World War II, and which sank on 5 April 1945, after being badly damaged by Japanese kamikaze attacks to the north of Okinawa. Compiled by a veterans' association, the collection includes a membership roster, historical clippings, photocopies of the association's newsletters, videotape cassettes, including 1 documenting the rediscovery of the ship's resting place, on 19 February 2001, and 2 videotapes by Japanese television network, NNN, broadcast on 1 July 2001.

Papers of George A. McLemore Sr. and George A. McLemore Jr. including photographs, articles, pamphlets, correspondence, audio recordings, and other papers.

Papers (1927-1963) consisting of correspondence, reference of Chinese social practices and customs, diaries, letters of missionaries, Chinese Civil War.

Includes Dr. Hunt's military records.

Communications from East Carolina University, Pitt County, and The United states regarding the COVID-19 Pandemic.

The Jack Minges Papers include photographs, clippings, and memorabilia related to the Minges family's relationship with East Carolina, especially the dedication of Minges Coliseum.

Files (1717-1957) of Murfreesboro, N.C. lawyers and Hertford County, N.C. officals, including correspondence, legal files, reports, financial records, etc. of B.B. Winborne, Attorney at Law, Winborne & Lawrence, Winborne and Winborne, Lemuel R. Jernigan and James L. Anderson.

Papers (1938–1993 [Bulk: 1938–1953]), of U.S. Naval Reserve officer and destroyer escort commander, including official files and service records, and a History of USS SC-631; postwar correspondence relating to the Destroyer Escort Commanders Organization (DECO); a History of the USS Kendall C. Campbell (DE-443), by Cdr. Richard E. Warner; a scrapbook, compiled by Cdr. Warner's father, entitled Sub Chaser Navy: World War II, which documented the achievements of destroyer escorts, and Warner's service in destroyer escorts, patrol craft, and sub-chasers; also oversize material including a blueprint of USS PC-497 [renamed SC-497]; and a laminated fact sheet entitled United States Ship USS Kendall C. Campbell (DE-443) including orders, letters, printed forms, certificates, commissions, and documents signed by Admiral Chester Nimitz; Secretaries of the Navy Frank Knox, Francis P. Matthews, Claude A. Swanson, and James Forrestal; by Governor of California Frank F. Merriam.

Memoir (1825-1970) including correspondence, certificates, letters, family records, picture, and a family tree with notes.