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Records (1950-2007) of Greenville Industries, including by-laws, certificate of incorporation, board minutes, correspondence, contracts, deeds, and blueprints, and of longtime board member and president Charles O'Hagan Horne, Jr. (1970-2000), including correspondence, financial records, blueprints, maps, and reports. Greenville Industries was a for-profit corporation founded to sell land at reduced rates to industries to encourage them to set up businesses in Pitt County, North Carolina.

The bulk of the collection (1841-1979) contains genealogical information about the Hollinger, Greenawalt, Little, and Iseminger families of Maryland and Pennsylvania. Other items include a journal (1855-1959) kept by three generations of the Little family, two very descriptive large paper broadsides announcing public sales of estates in Lemaster, Franklin Co., Pennsylvania (1907), and Upton, Pennsylvania (1904), World War I military Selective Service registration cards, correspondence, clippings, copies of recipe books, and financial records.

Collection contains material covering the term of Thomas B. Brewer as the second Chancellor of East Carolina University.

During the Civil War, Abijah Hollis of New Hampshire served with the 45th Regiment Massachusetts Volunteers as a second lieutenant in Company B under Colonel Charles R. Codman with heavy involvement in the North Carolina campaign, and in the 56th Regiment Massachusetts Volunteers. This collection consists of a typescript entitled STORIES OF THE WAR, FROM PERSONAL RECOLLECTIONS AND DIARIES, For My Children, A. Hollis, West Concord, N.H., January, 1884, and a transcriptrion by the donor with photographs; photocopies of official "carded medical records" for Hollis (1863-1864); copies of photographs of Hollis in uniform during the Civil War taken while stationed in New Berne (now New Bern), North Carolina, in his Union uniform with captain bars, in 1908-1910; and copies of photographs of Hollis's wife Harriette, his U.S. cartridge case, and his belt buckle used during the Civil War.

Records (ca. 1920-2007, n.d.) of the Lenoir County Historical Association include correspondence, minutes, financial records, membership records, building plans for Harmony Hall, museum artifact records, newspaper clippings, publications, photographs, calendars, and subject files.

Collection (1841-1959, undated) of manuscripts, genealogical materials, photographic prints and printed materials related to the James N. Dickey family of New York and Michigan and William Symington Brown, M. D., who served as a surgeon in the 33rd and 55th Massachusetts Infantry Regiment, 1863, during the Civil War. Unrelated is a photograph of U.S. Vice President Barkley attending a Roosevelt Dinner held at East Carolina Teachers College (now ECU) in 1950.

The collection contains a group of copied pages from several sources, with the cover page titled "Wood Tucker Johnson, M.D., Medical Lectures - University of Pennsylvania School of Medicine 1820-1823." Within these pages is a copy of a photograph (presumably of Johnson), a letter, copied pages from books, and complete typed versions of two books. Also in the collection are two handwritten books and Johnson's certificate of membership to the Philadelphia Medical Society and his University of Pennsylvania Medical School diploma.

This collection contains the administrative records of the College of Fine Arts and Communication.

This collection contains political brochures, posters, and mailings (1990s-2020) related to mainly Greenville, Pitt County, North Carolina and U.S. Congressional races although some relate to Presidential elections. The focus is on Democratic Party candidates, but also includes some items related to Republican Party rivals.

This collection contains records from the College of Allied Health Sciences. Many materials are unprocessed.

This collection contains photos from the Department of Kinesiology.

This record group contains the administrative records of the Division of Student Life.

This collection contains faculty minutes and a fact sheet about the Department of Finance.

This collection contains degree proposals, self-study materials, enrollment figures, correspondence, reports, unit code of operations, announcements, brochures, and publications by the Department of Geology.

This collection contains annual reports, meeting minutes, and self-studies from the Department of Physics.