Eugene Grissom was a Granville native who briefly studied law before he became a doctor. After Grissom matriculated from University of Pennsylvania in 1856 he returned to North Carolina to practice medicine. At the outbreak of the Civil War, Grissom recruited a regiment of North Carolina men and served until his injury in 1862. His injuries forced Grissom off the battlefield and into Confederate politics appointed to House of Commons and also called upon by Governor Vance to be a Major and full surgeon between legislative sessions. Following war, he established the Morganton Hospital.