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The collection includes materials (1898-1959) documenting the work of Shackleford Banks native Josiah Clark Chadwick working on freighters running from North Carolina to New York, and then with the Army Corps of Engineers in North Carolina (1927-1959) working the Eastern N.C. federal waterway projects on diesel engines and then inspecting dredges. Included are family history, Chadwick's work history, training materials, engineers' level books, logbooks, and inventories of engineering property in Chadwick's charge.

Collection (1820-1912) including correspondence, receipts, accounts, notes, etc. relating to three brothers who settled in Eastern North Carolina.

Collection (1883–1910) consisting of correspondence, eight Civil War pension application ledgers, 2 account books and church record book. The majority of the collection consists of claims for pensions by blacks who served in the U.S. Army and U.S. Navy during the Civil War. The claims request compensation for wounds and injuries received or diseases contracted by the applicants. Claims were submitted either by the veterans themselves or by their survivors. While the majority of claimants appear to have lived in the vicinity of New Bern and James City, North Carolina, many resided throughout the central portion of eastern North Carolina. The ledgers were once the property of Frederick Douglass, a black lawyer, minister, and teacher of New Bern who handled the claims.

Letters written by Victor C. Faure to his parents dated from May 18, 1918 to 27 March, 1919. Describe movement from California to Fort Mills on Long Island, to France, and delays in returning home after the war.

Collection (1910-1928, undated) of photocopies of correspondence, programs, and a volume relating to a Wilmington (NC) attorney, political leader, and mason. **Please note the collection is photocopies only. ECU does not own the originals.

Papers (1817-1902) consisting of deeds, receipts, clipping, account book, tintype, and a transfer of land related to Lenoir Co., North Carolina.

This donation consists of 35 cubic feet of records (1993-2014) documenting the NCEast Alliance organization under its previous names of North Carolina's Eastern Region (2005-2014) and Global TransPark Development Commission (1993-2005). NCEast Alliance is a regional economic development agency serving the thirteen counties in eastern North Carolina that surround the Global TransPark at Kinston, North Carolina.

The Rich Elkins Papers (1994-2002) is a collection of publications and clippings on the Lesbian, Gay, Bisexual, and Transgender communities in North Carolina, South Carolina, and New York with some of the materials from the LGBT community in Greenville, N.C. located in Eastern North Carolina. Richard "Rich" Elkins has been active in the Eastern N.C. LGBT community for many years and these materials reflect his involvement.

Collection (1766-1863, undated) including correspondence, accounts, etc., of the Skinner and Hoskins families, who were prominent families of Eastern North Carolina.

Material (1862-2017) including correspondence, manuscripts, photographs, narrative reminiscences, and a muster roll (1862) and other original documents related to Dr. William N. Still, Jr.'s career as a well-known and respected maritime historian and author. His research topics included shipbuilding in North Carolina, maritime history, and Naval history in the American Civil War through World War II.

Collection (1768, 1799, 1825-1865, 1887-1931, 1985) assembled by prominent Democratic politician, newspaper editor and historian Henry T. King (1861-1924) of Greenville, N.C. Included are the papers of Edward C. Yellowley (1821-1885), a Greenville, N.C., lawyer with particular emphasis on correspondence while he was serving as a Confederate officer in the Civil War; King's Weekly Newspapers (1895-1902); King's Sketches of Pitt County; and correspondence, speeches, verse, legal documents, clippings, broadsides, pamphlets, receipts, poetry, accounts, maps, and miscellany.

Collection (1973–1989) of color slides documenting J. Y. Joyner Library at East Carolina University, in October 1973, prior to the construction of two extra floors and the addition of a new west wing to the building, for Library Science 1000 class; also photocopies of correspondence, historical research reports, and newspaper clippings about the Greenville Town Common Confederate flags controversy, in 1983–1989; also photocopies of newspaper clippings about the Confederate flag, 1983–1989. Collection also contains 4 photographs of individuals from the Collins-Becton family.

Advertisements for medicine, likely from between 1870 and 1910. The advertisements include patent medicine trade cards, blotter paper advertisements, broadside advertising sheets, booklets, and calendars. "Patent medicines" were often promoted as "cure-alls" for many parts of the body and their ingredient list (if any) was often inaccurate.

Papers and artifacts, primarily notebooks, account books, journals, instruments, and devices of three generations of Alfred F. Hammond's, all physicians in eastern North Carolina.

The Edwin Monroe Papers include reports, correspondence, speeches and statements, newspaper clippings, ephemera, and photographs related to the ECU medical school.