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This collection contains a items related to student life and academics at East Carolina including certificates, event programs, brochures, and memorabilia.

Papers (1940–1945) of a U.S. Naval Reserve medical officer, including scrapbook of clippings, photographs, correspondence, photographs, original art, and memorabilia compiled while serving in the U.S. Naval Reserve at the Toledo, Ohio naval recruiting station, 1942–1943; And letters sent to his parents Dr. and Mrs. Carroll C. English, in Louisville, Kentucky, while serving aboard USS Trathen (DD-530), 4 April 1943–5 December 1944

Original material collected by Horace H. Mewborn, Jr. including printed maps, letters, diaries, clippings, cartes de visite, tintypes, an ambrotype, memoir, ledgers, reports, and drawings related to the Civil War especially pertaining to Col. John S. Mosby and his 43rd Virginia Cavalry Battalion, Col. Elijah V. White and his 35th Virginia Cavalry Battalion, North Carolina Cavalry Units, and the battles fought in the New Bern, NC, vicinity. Also included is his voluminous research related to the above listed units and the Army of Northern Virginia and the Army of the South.

Papers (1853-1937, undated) consisting of correspondence, financial and legal papers, letters, records of insurance, papers on business and farming, genealogical records, etc.

This collection (1924-2000) contains material related to the marketing of products produced by the Empire Brush Company of Greenville, North Carolina. Included are catalogues, price lists, marketing programs, advertising stickers and product wrappings, and original materials used in planographic printing of product wrappings. Although Empire Brush moved its manufacturing facility to Greenville Industrial Park in 1964, the collection also contains items relating to its pre-1964 years and some to Rubbermaid which bought Empire Brush out in 1994.

The collection includes publications created by the ECU School of Medicine and the University Health Systems of Eastern Carolina, formerly Pitt County Memorial Hospital.

Papers (1777-2022) relating to John Baxton Flowers III academic career, family history and Scottish genealogy (Flowers, Kennedy, and Thompson families of Wayne County, NC), historic preservation, horticulture and garden history. Included are correspondence, financial and legal papers, academic records, newspaper clippings, photographs, typescripts, genealogical material, publications, certificates, house plans, watercolor drawings, and newsletters.

Papers (1861-1864) including correspondence, letters, account of duties, detailed description of USS Brandywine, etc.

Papers, certificates, photos, and artifacts of Dr. Edwin Wall Monroe. This collection contains a great deal of information regarding the development of the East Carolina School of Medicine, including planning, politics, legislation, advertisement, construction, partnerships, details of the personnel involved, groundbreakings and other ceremonies, departments, additional buildings, and community services.

Papers (1915-1975) of Edenton NC Funeral parlor operators, including correspondence, funeral service ledger, photographs, and miscellany. 200 items.

Papers (1921-2002) musical scores, published sheet music and lyrics, biographical articles, contracts, LPs, cassettes, videotapes, reel to reel tapes, compact discs, clippings and photographs pertaining to noted North Carolinian Loonis R. McGlohon's career as a musical composer, arranger, orchestra leader and performer of jazz, popular and sacred music. Many items also relate to McGlohon's personal life such as photographs, reel to reel tapes of family events, passports, deeds, wills, death and birth certificates, military discharge papers and correspondence with well-known musicians, actors and political figures.

The C. B. West collection consists of a ledger documenting construction projects of C. B. West and his son in Greenville and other cities; and materials purchased from such suppliers as W. H. Dail of Greenville; and three Greenville Mayor's Court record books documenting minor crimes in Greenville.

Collection (25 November – 21 December 1862) including holograph letters written by 1st Lt. Frank W. Adams, Company B, 51st Massachusetts Volunteer Infantry, to his sister Elizabeth in Massachusetts, describing in great detail on the regiment's departure from the Boston Harbor aboard the Steamer Merrimac, voyage to North Carolina, their arrival in Newbern [New Bern], N.C. their encounter with the 43rd Massachusetts and their participation in the Battles of Kinston and Whitehall (present day White Hall), North Carolina as part of General John G. Foster's Goldsborough [Goldsboro] Expedition; also transcript of the holograph letters and one additional letter; also folios that formerly contained the letters and transcripts. Note: the letter dated 10-21 December 1862 also contains an envelope containing remnants of the ribbons once used to bind the letters; the folder that held the transcripts is stamped inside the font cover: "Robert W. Adams Oct. 1, 1947".