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The Harnett County Common Schools Collection contains a few pages from a Common School Register (1879) from a school for African American students, in District No. 1, Harnett County, North Carolina.

This collection consists of an autograph book possibly kept by Elizabeth Williams while she was attending Greenville High School in Greenville, North Carolina. The entries have dates for 1942 and 1943. Besides having comments and poems written by her girlfriends, there are also entries written by members of the military forces (during World War II) and a listing of local men and what branch of the military they belong to. This autograph book was found in the attic of 2707 E. Third St. in Greenville, N.C.

Seven engravings of University of Pennsylvania medical school faculty.

Records from the College of Allied Health Sciences at East Carolina University tracking the development of the school. Also includes three editions of Alliance, the journal produced by the school.

The collection consists primarily of photographic, blueprint, journals, class photos, and other advertising materials used and/or created by the Medical News & Information department of East Carolina University.

This collection contains materials and documents (1893–1990s) relating to the history of Pitt County, North Carolina Schools, highlighting especially the era of segregation. Includes Registers (1893-1920); football pamphlets (1969–1978) for J.H. Rose High School; Statement of Funds Needed Provided by Pitt County for both "Colored" and "White" schools (1916-1917); a letter (1924) from G.R. Whitfield, Supervisor for "Colored" schools; scrapbooks, scrapbook materials, and news clippings (1970s–1990s) for Third Street School, C.M. Eppes, Greenville Middle School, Agnes Fullilove School and other Pitt County schools; building specifications (1968-1973) related to Pitt County Schools; John Edwin Scoville Memorial Cups (1923-1928).

Survey (1934) including photographs of schools, option to buy property, information on property location, weather, type of roof, etc.

This collection contains five photographs. These photographs show the J. R. and J. G. Moye Store on Evans St. in Greenville in the 1910s, the Amoco Dealers conventions in Washington, D.C.,and the most recent photograph comes from the late 1980s or early 1990s of the Pitt County, N.C., Sheriff's Department and includes coroner E. W. Harvey, Jr.

This collection contains records documenting the functioning and history of the Graduate School. It includes annual reports and printed publications.

This collection contains Souvenir Programs from High School Day, which were intended to provide high school students with information about East Carolina.

This collection contains copies of the ECU Medical Review and later iterations of the publication.

This collection contains records of the School of Hospitality Leadership.

The Creative Learning Center provides adult day care services in Greenville North Carolina. In the mid- 1980s, the East Carolina School of medicine donated $100,000 to start a satellite center in Farmville, NC. This file contains clippings, brochures, and photographs related to the opening of the Farmville satellite center.