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Collection contains a variety of items relating to Eastern North Carolina especially including a photograph of East Carolina Teacher's College scene (ca. 1940's); a theater Program (ca. 1933/34) for a play presented by The Episcopal Junior Guild, Austin Building, East Carolina Teacher's College; and a Measles in Quarantine Keep Your Babies Away From Measles Broadside (4/7/1934) posted on the home of Ella Viola McGowan when she had the measles. Also included are photographs (some unidentified) of World War II era of which several pertain to military bases such as the 657th Engineer Topographic Battalion (40th Infantry Division, U.S. Army), and one is of Cecil May in U.S. Marine corporal uniform; a photocopy of a letter (1913) containing reminiscences of Confederate veteran John W. Vernelson (of N.C. State Troops) war service and describing the Veterans Reunion at Gettysburg, PA; receipts (1909-1910) for sales by Crown Bottling Works in New Bern, NC; Pitt County, NC, land grants and deeds (1782-1837) related to the Boyd, Edwards, and Nobles families; Bible Records and birth and death records for the Eldridge, Wilder/Hatsell, Pittman, Moore, Sewell, and Davis families; and the book (2011) "One of the Lucky Ones," Edgar Cannon's Contributions in World War II. Other materials (1856-2001) consist of manuscripts, research clippings, notes, photocopies, photographic prints, programs, notebooks, and newspapers, relating to the history and genealogy of Eastern North Carolina, especially Robersonville and Williamston in Martin County, NC. Also included are a 1941 color silent 16mm film about Greenville and slides (ca. 1970) documenting tobacco and old houses in Pitt County, NC.

Artwork and prints, primarily oversized, found in Country Doctor Museum items. Includes prints from "A History of Pharmacy in Pictures," "A History of Medicine in Pictures," "History of Anesthesia in Pictures," "Gay Philosopher" by Henry Major, "Pioneers of American Medicine" by Dean Cornwell, and other prints.

Papers (1772, 1816-1927) including correspondence, legal papers, deeds and estate papers, financial papers, speeches, stories and poems, clippings, photographs, ledgers, medical bills, services rendered, charges and payments, etc.

Collection (1863-1865) related to the American Civil War and Andrew Giddings of Company E, 3rd North Carolina infantry. Includes Oath of Allegiance to the United States signed by Andrew Giddings on November 6, 1865 [Following the American Civil War, Confederate officials, veterans and prisoners of war were obliged to sign an "oath of allegiance" to regain their civil rights under the U. S. Constitution.]. The collection also includes a note concerning the capture of Washington Rose, a member of Company C, 6th Louisiana Regiment at the Battle of the Wilderness. Most significantly, the collection contains Andrew Giddings' leather-bound diary and ledger of income and expenses, which includes eyewitness accounts of the engagements in which he participated, including Gettysburg, Cold Harbor, Sharpsburg, Malvern Hill, 2nd Winchester, Chancellorsville, and Wilderness. It also includes descriptions of his capture and imprisonment in a Union prisoner of war camp. The collection also includes an envelope that held the diary with "Granddad Giddings Diary" written on it.

Collection (1942-2005) of materials belonging to Wray Raphael Herring, a member of the U.S. Navy B-1 Band which was the first all-African American Navy Band during World War II. Included are programs, clippings, sound recordings, yearbooks, concert programs, poems, and sheet music.

Papers of physician William Ernest Evans, including "The Physician's Perfect Call List and Record" notebook and a newspaper clipping of "Brotherhood."

Oral history interview with prominent African American businessman and political leader of Greenville, North Carolina, named Denison D. "D.D." Garrett, Sr. He discusses his background, education, business pursuits, and political involvement including race relations in Greenville and Pitt County, especially during the Civil Rights era.

This collection contains 8" x 10" photographs taken by Edwin A. Martin when he was a professor in the Philosophy Department at North Carolina State University and Curator of Photography at the North Carolina State University Visual Arts Center in the 1990s. The tobacco images cover a season of tobacco farming in the Wendell, North Carolina, area from planting through auction. The images of Harkers Island, North Carolina, document the daily life of the local fishing population. A 1998 publication Hope for a Good Season containing some of these Harkers Island photographs is also included.

The collection is comprised of papers written by William Jasper and collected over his career, focusing on dental health, along with class notes from the University of Pennsylvania and articles he wrote.

The collection is comprised of papers from Dr. I. Henderson Lutterloh and his son Dr. I. Hayden Lutterloh. It includes correspondence, licenses and receipts from Lutterloh Clinic and Drugstore, medical informational booklets, and handwritten notes from Hayden's education at Jefferson Medical College. Also included is a book based on Hayden's recollections of medicine in Sanford beginning with his father.

Papers (1908 – 1986, undated [bulk: 1964 – 1986]) of John Porter East, including biographical, genealogical, and historical materials relating to his life (b. 5 May 1931 – 29 June 1986) ; his marriage to Priscilla Sherk East and their children; his service as an officer in the U. S. Marine Corps; his battle against poliomyelitis and the paralysis it caused; his graduate studies in political science and as a professor of Political Science at East Carolina University, 1964 – 1980, including his teaching files for each of his classes, his academic and professional publications, speeches, interviews; and also his conservative Republican political beliefs and affiliations and political career, including his several unsuccessful attempts to win political office in North Carolina, 1966 – 1976, culminating in his successful campaign for and election to the United States Senate in 1980; but the bulk of the collection focuses on his service in the Senate, where he was aligned with Senator Jesse Helms (R-NC) and a member of Helms' political organization, the Congressional Club; including his mailing lists, correspondence and constituent cases and projects files; his office and staff files, including files of this administrative assistants, press secretaries and legislative assistants; his political patronage and nomination files, committee and legislative activities; his voting records, newsletters, voluminous clipping files, press and public relations files, including publications, audio and video of interviews, speeches, and political events; his frequent bouts of ill health due to poliomyelitis, hyperthyroidism, urinary tract blockages, and depression, and their side effects which may have contributed to his death by suicide; also including photographic prints and negatives, microfilm of committee records, correspondence, case and general files, voter registration files; and also oversized materials, 1981 – 1986, undated.

This collection contains nine cased daguerreotypes and ambrotypes (and one ambrotype missing the case) of images that come from the White family of White's Mill and then later nearby Spartanburg, South Carolina. Images are probably from the 1850s and 1860s and include individual images of young boys, young girls, a woman, two images of the same woman, and an enslaved or formerly enslaved African American woman holding a white baby. The images were found among the effects of John Hamlin "Hamp" White (deceased November 23, 1949), son of Alexander Lawrence White (1860-1942). Hamp White was married to Mary Erwin, the aunt of the donor.

This collection includes 13 pieces of correspondence addressed to Mathias Embry of Vincennes, Indiana during the years 1863-1864. The bulk of the collection was written by or about John Posey (1842?-1864) and Charles Newton (1843?-1864), both Black soldiers who served in the 55th Massachusetts Volunteer Regiment. The letters provide a glimpse of the experience and motivation of Black soldiers serving during the Civil War and the effect of the war on both the enlisted and non-combatants.