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Collection (1766-2010) consists of items related to the Augustus Moore (June 8, 1803-March 23, 1851) family of Chowan and Halifax Cos., N.C., his children Augustus Minton Moore, William Armistead Moore, Henrietta Moore Sutton, Susan Augustus Moore Righton, Mary Elizabeth Moore, Alfred Moore and John Armistead Moore, and the descendants of John Armistead Moore. Included are account books, legal records, land transactions, estate records, correspondence, clippings, and autograph books (1855, 1865) belonging to family members who attended Miss Willard's Female Seminary in Troy, N.Y., and Patapsco Female Institute in Ellicott City, Maryland. Also included are identified photographs (cartes de visite, tintypes, cased pictures, albums) of the Moore, Gilliam, and Skinner, families, religious books such as Roman Catholic Missals, Episcopal Books of Common Prayer and Bibles, UNC-Chapel Hill diplomas (1824), and items related to the 1878 Exposition in Paris, France.

This collection primarily contains physical and digital photographs of descendants of Willie Brown (1799-1867) and Nancy Moye Brown of Greenville and Pitt County, North Carolina, especially through the line of their son Dr. William Moye Benjamin Brown (1823-1903) and his wife Jane Marie Greene.

Collection (1841-1968) including correspondence, legal papers, accounts, receipts, pamphlets, clippings, photographs, poems, pocket ledgers, Civil War correspondence, letters and miscellaneous.

Papers (1863, 1946-1967) including correspondence, speeches, news releases, pamphlets, etc. relating to a local leader in the Ku Klux Klan in Eastern North Carolina.

Papers (1912-1965, undated) consisting of correspondence, diaries of missionary activities, letters, Genealogical information.

Included are a copy of the Daniels-Murphrey Family History compiled and edited by Eleanor Daniels Casey in 1993, a photograph of the USS Nebraska that Benjamin Daniels of Wayne County, North Carolina, sailed to Europe on in WWI, and three photographs of Benjamin Daniels in his WWI US Navy uniform.

Papers of Richard Herman McLawhorn, Jr. (1923-1987) of Ayden Township, Pitt County, North Carolina that are related to his childhood and his service during World War II as a bombardier on the bomber "Tail Heavy" with the U.S. Army Air Corps 485th Bomb Group.

Collection (1932-1975) of correspondence, clippings, and yearbooks compiled by Harriett Roseveare and Carolyn James, who served as club officers, relating to club membership and activities in support of World War I and II, including sale of war bonds, United Nations Day, home economics education, Green Springs Park, Parent - Teacher Associations, nursery schools and night schools, social events and scholarships for teenagers, Community Fine Arts Festival, Pitt General Hospital, Pitt County Fair, and other activities.

The Woman's Club of Greenville, NC, was founded in April 1917 intending to raise Greenville to be equal with other cities in the state. Catherine "Kitty" Smith Joyner (b. 4 June 1932 – d. 2 Aug 2011), a native of Greenville N.C., worked with the Woman's Club of Greenville, NC, in the 1990's. This collection includes photographs of Greenville, N.C., and other locations in Pitt County, as well as a publication detailing the first fifty years of the Woman's Club of Greenville, NC.

This collection consists of the records of the Institute of Outdoor Theatre which was founded in 1963 and includes material related to over 600 outdoor theatres, some of which began operation in the 1920s. Included are play scripts, correspondence, clippings, publicity material, video and audio recordings, feasibility studies, publications, reel-to-reel tapes, 35 mm slides, blueprints, and audition-related materials. This collection is being processed with the support of a National Historical Publications and Records Commission grant.

Papers (1928-1979) including correspondence, memorandums, classified and unclassified documents, military records, reports, poems, photographs, yearbooks, news articles, maps, regulations, and miscellaneous.

Collection (1908-1910) of postcards addressed to Miss Augusta Oden, Pinetown, NC by Bettie, Mrs. J. W. Thomas, Miss Josephine, & M. in Washington, NC; Henry in Morehead City, NC; and J.S.L. in Greenville, NC. Postcards show scenes of Greenville, NC: Evans St. Looking North; Morehead City, NC: Atlantic Hotel, Washington, NC: Washington Court House, Washington Hospital, Main St. Looking West (2), Main St. Looking East. 4 colored, 3 B & W postcards.

Negatives, slides, photograph contact sheets, reports and news releases from the Medical Center News and Information office at East Carolina University.

Collection (1820-1912) including correspondence, receipts, accounts, notes, etc. relating to three brothers who settled in Eastern North Carolina.

Papers (1873, 1892-2009, undated) concerning Littleton Female College (later called Littleton College) in Warren County, North Carolina, and its alumnae include correspondence, programs, college history, alumnae lists, clippings, pamphlets and speeches, etc. The college opened in 1882 and closed after a disastrous fire in 1919. The Littleton College Memorial Association was founded in 1926.