The papers primarily consist of correspondence and financial papers concerning personal, business, medical, and collegiate interests.
Correspondence with Sam Underwood, Ben Wyche's brother-in-law and lawyer, concerns the sale of Wyche's Store in exchange for cash and stocks in Merchants Distributing Company. Other correspondence focuses on the takeover of Hanover Distributors by Ben and John Wyche.
As trustee of the Alice V. Wyche Trust Fund, Ben Wyche was responsible for the purchase, sale, and selection of investments for the trust fund. Correspondence also concerns the purchase and sale of stock for Ben Wyche himself. Major areas of investment include insurance, banking, industry, and trucking.
This collection also contains medical correspondence (1945-1974) concerning Wyche's ailments, correspondence with a friend from Wadesboro (1970-1972), as well as correspondence with Davidson College (1959-1963) concerning the interest of various local high school seniors in the institution and class reunions.